Evidence map›Paper›PMID 31548295›Full record

ArticleMolecular cancer therapeutics2020

Blockade of Glutathione Metabolism in

Xiaoying Tang, Xiao Fu, Yang Liu, Di Yu, Sabrina J Cai, Chunzhang Yang

Open access · greenAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 110 citations in OpenAlex.

  1. Article
  2. A BBB-permeable βScience advances · 2026
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  15. Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Xiaoying TangSchool of Life Science and Technology, Beijing Institute of Technology, Beijing, China.
Xiao FuSchool of Life Science and Technology, Beijing Institute of Technology, Beijing, China.
Yang LiuNeuro-Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland.
Di YuNeuro-Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland.ORCID 0000-0003-0801-1225
Sabrina J CaiNeuro-Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland.
Chunzhang YangNeuro-Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland. yangc2@nih.gov.ORCID 0000-0001-6433-0867
Center for Cancer Research · USBeijing Institute of Technology · CN

Funding

Investigation on the biology of IDH mutant gliomaZIABC011684 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YANG, CHUN ZHANG · 2016 to 2025
$3.6M
Nrf2-goverened metabolic reprogram in IDH1-mutated gliomaZIABC011761 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YANG, CHUN ZHANG · 2017 to 2025
$3.4M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA BC011684
6 · The paper itself

Abstract

Mutations in genes encoding isocitrate dehydrogenases (

Indexed as

AnimalsCell Line, TumorCell SurvivalGliomaGlutathioneHumansIsocitrate DehydrogenaseMiceMutationNF-E2-Related Factor 2Oxidative StressQuassinsReactive Oxygen SpeciesXenograft Model Antitumor AssaysbrusatolGlutathioneIDH1 protein, humanIsocitrate DehydrogenaseNFE2L2 protein, humanNF-E2-Related Factor 2QuassinsReactive Oxygen Species

Identifiers

PMID31548295
PMCPMC6946871
OpenAlexW2976324426

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.