Evidence map›Paper›PMID 31548277›Full record

ReviewJournal of bacteriology2019

"It Takes a Village": Mechanisms Underlying Antimicrobial Recalcitrance of Polymicrobial Biofilms.

Giulia Orazi, George A O'Toole

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Journal of bacteriology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05239312 (Antibiogram and Biofilm Formation of Bacteria Causing Prosthetic Joint Infections Isolated From Assiut University Hospital), which is not on this map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05239312 unknown statusnot on this mapstarted 2022, after this paper: background citation

Antibiogram and Biofilm Formation of Bacteria Causing Prosthetic Joint Infections Isolated From Assiut University Hospital

TypeobservationalSponsorAssiut UniversityRan2022 to 2024Enrolled90ConditionsProsthetic Joint InfectionArmsAntimicrobial
3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 176 citations in OpenAlex.

  1. Diabetes-associatedMicrobiology spectrum · 2026
    Observational
  2. The metabolic trap:Journal of medical microbiology · 2026
    Article
  3. Effects of Tranexamic Acid in Combination with Teicoplanin AgainstInternational journal of molecular sciences · 2026
    Article
  4. Review
  5. Review
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  13. Review
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  15. Mapping the knowledge landscape ofFrontiers in cellular and infection microbiology · 2026
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Giulia OraziDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
George A O'TooleDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA georgeo@dartmouth.edu.ORCID 0000-0002-2861-4392
Dartmouth College · US

Funding

HOST-MICROBE INTERACTIONST32AI007519 · NIAID · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 1997 to 2026
$5.9M
cdiGMP regulation of Biofilm FormationR37AI083256 · NIAID · DARTMOUTH COLLEGE · PI O'TOOLE, GEORGE A. · 2014 to 2023
$4.7M
NIAID NIH HHS R37 AI083256NIAID NIH HHS T32 AI007519
6 · The paper itself

Abstract

Chronic infections are frequently caused by polymicrobial biofilms. Importantly, these infections are often difficult to treat effectively in part due to the recalcitrance of biofilms to antimicrobial therapy. Emerging evidence suggests that polymicrobial interactions can lead to dramatic and unexpected changes in the ability of antibiotics to eradicate biofilms and often result in decreased antimicrobial efficacy

Indexed as

Drug Resistance, Microbialbeta-LactamasesBiofilmsCell WallHydroxyquinolinesMicrobial Sensitivity TestsMicrobiotaQuorum Sensing2-(n-heptyl)-4-hydroxyquinoline N-oxidebeta-LactamasesHydroxyquinolinesantibioticsbiofilmpolymicrobialrecalcitranceresistancetolerance

Identifiers

PMID31548277
PMCPMC6932244
OpenAlexW2976167551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.