Evidence map›Paper›PMID 31548262›Full record

ArticleMolecular and cellular biology2019

Ectopic Methylation of a Single Persistently Unmethylated CpG in the Promoter of the Vitellogenin Gene Abolishes Its Inducibility by Estrogen through Attenuation of Upstream Stimulating Factor Binding.

Lia Kallenberger, Rachel Erb, Lucie Kralickova, Andrea Patrignani, Esther Stöckli, Josef Jiricny

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Aging · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lia KallenbergerInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
Rachel ErbInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
Lucie KralickovaInstitute of Biochemistry, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland.
Andrea PatrignaniFunctional Genomics Center of the University of Zurich and the ETH Zurich, Zurich, Switzerland.
Esther StöckliInstitute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Josef JiricnyInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland jjiricny@ethz.ch.ORCID 0000-0002-1831-8186
University of Zurich · CHETH Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The enhancer/promoter of the vitellogenin II gene (

Indexed as

AnimalsBinding SitesCell LineChick EmbryoCpG IslandsDNA-Binding ProteinsDNA-Cytosine MethylasesDNA MethylationEctopic Gene ExpressionEstrogen Receptor alphaEstrogensGene Expression RegulationGenes, ReporterHumansPromoter Regions, GeneticRegulatory Sequences, Nucleic AcidDNA-Binding ProteinsDNA-Cytosine MethylasesDNA modification methylase SssIEstrogen Receptor alphaEstrogensTranscription FactorsVitellogeninsDNA demethylationDNA methylationE-boxestrogen inducibilitygene expressionUSF1USF2vitellogenin

Identifiers

PMID31548262
PMCPMC6851352
OpenAlexW2973728664

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.