ArticleJournal of translational medicine2019
The role of radiotherapy in metaplastic breast cancer: a propensity score-matched analysis of the SEER database.
Article in Journal of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Beyond the Triple-Negative Label: A Case Report on Metaplastic Breast Carcinoma.Clinical case reports · 2026Article
- Secondary Cancer Risk in Breast Cancer with and without Radiotherapy: The Observational Health Data Sciences and Informatics (OHDSI) Cohort Study.Cancer research and treatment · 2026Observational
- The Metaplastic Conundrum: A National Cancer Database Analysis of Metaplastic versus Triple-Negative Ductal Breast Cancer.Annals of surgical oncology · 2025Article
- Chemotherapy as a critical treatment modality for non-surgical metaplastic breast cancer: evidence from SEER database and clinical cohort.Frontiers in oncology · 2025Article
- A comprehensive overview of metaplastic breast cancer: Features and treatments.Cancer science · 2024Review
- A rare case of metaplastic breast carcinoma from India: Towards precision oncology.Cancer reports (Hoboken, N.J.) · 2024Article
- Metaplastic Breast Cancer: Current Understanding and Future Directions.Clinical breast cancer · 2023Review
- Recurrent Metaplastic Breast Cancer with Subtype Converted from Triple-Negative to HER2-Positive: A Case Report and Literature Review.Breast cancer (Dove Medical Press) · 2023Article
- Construction and validation of prognostic nomogram for metaplastic breast cancer.Bosnian journal of basic medical sciences · 2022Article
- The Effect of HER2 Status on Metaplastic Breast Cancer A Propensity Score-Matched Analysis.Frontiers in endocrinology · 2022Article
- Establishment of prognostic model for postoperative patients with metaplastic breast cancer: Based on a retrospective large data analysis and Chinese multicenter study.Frontiers in genetics · 2022Article
- [Effect of postmastectomy radiotherapy on survival outcomes of patients with metaplastic breast cancer].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Clinicopathological and Radiological Features with Long Term Follow Up of Metaplastic Carcinoma Breast in India.Asian Pacific journal of cancer prevention : APJCP · 2021Observational
- Clinicopathologic and genetic features of metaplastic breast cancer with osseous differentiation: a series of 6 cases.Breast cancer (Tokyo, Japan) · 2021Article
- Nomogram for predicting preoperative regional lymph nodes metastasis in patients with metaplastic breast cancer: a SEER population-based study.BMC cancer · 2021Article
- The Effect of Post-Mastectomy Radiotherapy in Patients With Metaplastic Breast Cancer: A Propensity Score-Matched Analysis of the SEER Database.Frontiers in oncology · 2021Article
- The Role of Adjuvant Chemotherapy in Metaplastic Breast Carcinoma: A Competing Risk Analysis of the SEER Database.Frontiers in oncology · 2021Article
- Article
- Adjuvant chemotherapy could benefit early-stage ER/PR positive mucinous breast cancer: A SEER-based analysis.Breast (Edinburgh, Scotland) · 2020Article
- A comprehensive overview of metaplastic breast cancer: clinical features and molecular aberrations.Breast cancer research : BCR · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 4 countries.
Funding
Abstract
backgroundOnly few studies, with small patient cohorts, have evaluated the effect of radiotherapy (RT) for metaplastic breast cancer (MBC). Hence, it is important to investigate the role of RT in MBC survival using a large population-database.
methodsA retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) from 1973 to 2015 was performed. We compared MBC patients with or without RT for overall survival (OS) and breast cancer-specific survival (BCSS) using univariate and multivariate Cox proportional hazard regressions before and after propensity score matching (PSM).
resultsFrom a total of 2267 patients diagnosed with MBC between 1998 and 2015, 1086 (47.9%) received RT. In the multivariate analysis before PSM, RT provided a better OS (HR 0.73; 95% CI 0.61-0.88; p = 0.001) and BCSS (HR 0.71; 95% CI 0.58-0.88; p = 0.002). Multivariate analyses after PSM (n = 1066) confirmed that patients receiving RT (n = 506) survived longer than those without RT (OS, HR 0.64; 95% CI 0.51-0.80; p < 0.001 and BCSS, HR 0.64; 95% CI 0.50-0.83; p = 0.001). A longer OS was observed when RT was given to older patients (p = 0.001) and in case of large tumor size (p = 0.002). Intriguingly, patients with N0 stage showed better OS after RT (HR 0.69, P = 0.012).
conclusionsOur findings support the beneficial effect of RT for MBC patients. In particular, older patients or with large tumor size have a greater survival benefit from RT. In conclusion, we have assessed the importance of the use of RT in MBC as survival factor and this could lead to the development of guidelines for this rare sub-type of tumors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.