ArticleBMC molecular biology2019
Overlapping transcriptional expression response of wheat zinc-induced facilitator-like transporters emphasize important role during Fe and Zn stress.
Article in BMC molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- PGPR-induced regulation of Zn and Fe transporters in wheat (Triticum aestivum L.) uncovered through integrated genome-wide analysis and functional validation.BMC plant biology · 2026Article
- Micronutrient Biofortification in Wheat: QTLs, Candidate Genes and Molecular Mechanism.International journal of molecular sciences · 2025Review
- Variation at the major facilitator superfamilyFrontiers in plant science · 2025Article
- Biofortification of Triticum species: a stepping stone to combat malnutrition.BMC plant biology · 2024Review
- Genome resequencing and transcriptome profiling reveal molecular evidence of tolerance to water deficit in barley.Journal of advanced research · 2023Article
- Multi-Omics Uncover the Mechanism of Wheat under Heavy Metal Stress.International journal of molecular sciences · 2022Review
- Identification of Zinc Efficiency-Associated Loci (International journal of molecular sciences · 2022Article
- Genomic approaches for improving grain zinc and iron content in wheat.Frontiers in genetics · 2022Review
- Strategies and Bottlenecks in Hexaploid Wheat to Mobilize Soil Iron to Grains.Frontiers in plant science · 2022Review
- Article
- Genetic Insight Into the Insect Resistance in Bread Wheat Exploiting the Untapped Natural Diversity.Frontiers in genetics · 2022Article
- Diverse Functions of Plant Zinc-Induced Facilitator-like Transporter for Their Emerging Roles in Crop Trait Enhancement.Plants (Basel, Switzerland) · 2021Review
- Mapping Resistance to ArgentineanInternational journal of molecular sciences · 2021Article
- Zinc toxicity in plants: a review.Planta · 2021Review
- Annotation and Molecular Characterisation of theGenes · 2021Article
- Biofortification and bioavailability of Zn, Fe and Se in wheat: present status and future prospects.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Review
- Effects of foliar fungicide on yield, micronutrients, and cadmium in grains from historical and modern hard winter wheat genotypes.PloS one · 2021Article
- Review
- Gene Expression Pattern of Vacuolar-Iron Transporter-Like (VTL) Genes in Hexaploid Wheat during Metal Stress.Plants (Basel, Switzerland) · 2020Article
- Identification of QTLs Containing Resistance Genes for Sclerotinia Stem Rot inFrontiers in plant science · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHexaploid wheat is an important cereal crop that has been targeted to enhance grain micronutrient content including zinc (Zn) and iron (Fe). In this direction, modulating the expression of plant transporters involved in Fe and Zn homeostasis has proven to be one of the promising approaches. The present work was undertaken to identify wheat zinc-induced facilitator-like (ZIFL) family of transporters. The wheat ZIFL genes were characterized for their transcriptional expression response during micronutrient fluctuations and exposure to multiple heavy metals.
resultsThe genome-wide analyses resulted in identification of fifteen putative TaZIFL-like genes, which were distributed only on Chromosome 3, 4 and 5. Wheat ZIFL proteins subjected to the phylogenetic analysis showed the uniform distribution along with rice, Arabidopsis and maize. In-silico analysis of the promoters of the wheat ZIFL genes demonstrated the presence of multiple metal binding sites including those which are involved in Fe and heavy metal homeostasis. Quantitative real-time PCR analysis of wheat ZIFL genes suggested the differential regulation of the transcripts in both roots and shoots under Zn surplus and also during Fe deficiency. Specifically, in roots, TaZIFL2.3, TaZIFL4.1, TaZIFL4.2, TaZIFL5, TaZIFL6.1 and TaZIFL6.2 were significantly up-regulated by both Zn and Fe. This suggested that ZIFL could possibly be regulated by both the nutrient stress in a tissue specific manner. When exposed to heavy metals, TaZIFL4.2 and TaZIFL7.1 show significant up-regulation, whereas TaZIFL5 and TaZIFL6.2 remained almost unaffected.
conclusionThis is the first report for detailed analysis of wheat ZIFL genes. ZIFL genes also encode for transporter of mugineic acid (TOM) proteins, that are involved in the release of phytosiderophores to enhance Fe/Zn uptake. The detailed expression analysis suggests the varying expression patterns during development of wheat seedlings and also against abiotic/biotic stresses. Overall, this study will lay foundation to prioritize functional assessment of the candidate ZIFL as a putative TOM protein in wheat.
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