Evidence map›Paper›PMID 31547617›Full record

ArticleViruses2019

Plant-Derived Purification, Chemical Synthesis, and In Vitro/In Vivo Evaluation of a Resveratrol Dimer, Viniferin, as an HCV Replication Inhibitor.

Sungjin Lee, Karabasappa Mailar, Mi Il Kim, Minkyung Park, Jiseon Kim, Dal-Hee Min, Tae-Hwe Heo, Soo Kyung Bae, Wonjun Choi, Choongho Lee

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022
    Review
  7. Nutrients · 2021
    Article
  8. Review
  9. Antiviral Properties of Polyphenols from Plants.Foods (Basel, Switzerland) · 2021
    Review
  10. Article
  11. Grapevine as a Rich Source of Polyphenolic Compounds.Molecules (Basel, Switzerland) · 2020
    Review
  12. Review
  13. Natural and nature-inspired stilbenoids as antiviral agents.European journal of medicinal chemistry · 2020
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sungjin LeeCollege of Pharmacy, Dongguk University, Goyang 10326, Korea. flatronsky@gmail.com.
Karabasappa MailarCollege of Pharmacy, Dongguk University, Goyang 10326, Korea. kitty_1506@yahoo.com.
Mi Il KimCollege of Pharmacy, Dongguk University, Goyang 10326, Korea. mi-il0826@naver.com.
Minkyung ParkCollege of Pharmacy, Dongguk University, Goyang 10326, Korea. minkyung-p@naver.com.ORCID 0000-0002-0121-7354
Jiseon KimCollege of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon 14662, Korea. odri1@naver.com.
Dal-Hee MinDepartment of Chemistry, Seoul National University, Seoul 08826, Korea. dalheemin@snu.ac.kr.
Tae-Hwe HeoCollege of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon 14662, Korea. thhur92@catholic.ac.kr.
Soo Kyung BaeCollege of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon 14662, Korea. baesk@catholic.ac.kr.
Wonjun ChoiCollege of Pharmacy, Dongguk University, Goyang 10326, Korea. mp89@dongguk.edu.ORCID 0000-0002-2342-0468
Choongho LeeCollege of Pharmacy, Dongguk University, Goyang 10326, Korea. choongholee@dongguk.edu.ORCID 0000-0002-4630-8428
Dongguk University · KRCatholic University of Korea · KRSeoul National University · KRThe Catholic University of Korea Bucheon St. Mary's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oligostilbenoid compounds, a group of resveratrol multimers, display several anti-microbial activities through the neutralization of cytotoxic oxidants, and by inhibiting essential host and viral enzymes. In our previous study, we identified a series of oligostilbenoid compounds as potent hepatitis C virus (HCV) replication inhibitors. In particular, vitisin B, a resveratrol tetramer, exhibited the most dramatic anti-HCV activity (EC

Indexed as

AnimalsAntiviral AgentsBenzofuransCell Line, TumorCell SurvivalDEAD-box RNA HelicasesGenotypeHepacivirusHumansMiceMolecular StructureNucleoside-TriphosphataseRepliconResveratrolSerine EndopeptidasesStilbenesAntiviral AgentsBenzofuransDEAD-box RNA Helicasesepsilon-viniferinNS3 protein, hepatitis C virusNucleoside-TriphosphataseResveratrolSerine EndopeptidasesStilbenesViral Nonstructural ProteinsViral Proteasesantiviral activityhepatitis C virus (HCV)NS3 helicase inhibitorpharmacokineticsviniferin

Identifiers

PMID31547617
PMCPMC6832221
OpenAlexW2973497883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.