Evidence map›Paper›PMID 31547597›Full record

ArticleJournal of clinical medicine2019

Association Between HDL Cholesterol and QTc Interval: A Population-Based Epidemiological Study.

Rosaria Del Giorno, Sofia Gabutti, Chiara Troiani, Kevyn Stefanelli, Raffaele Falciano, Elisa Graziano, Tommaso Rochat Negro, Luca Gabutti

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Long QT: Time to cut cholesterol?International journal of cardiology. Heart & vasculature · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Arterial Stiffness and Central Hemodynamics are Associated with Low Diurnal Urinary Sodium Excretion.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Rosaria Del GiornoDepartment of Internal Medicine and Nephrology, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland. rosaria.delgiorno@eoc.ch.ORCID 0000-0001-5206-8865
Sofia GabuttiDepartment of Internal Medicine and Nephrology, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland. gabuttisofia@gmail.com.
Chiara TroianiDepartment of Internal Medicine and Nephrology, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland. chiara.troiani@students.uniroma2.eu.
Kevyn StefanelliDepartment of Social Sciences and Economics; Sapienza University of Rome, 00185 Rome, Italy. kevyn.stefanelli@gmail.com.ORCID 0000-0001-9339-8860
Raffaele FalcianoDepartment of Internal Medicine and Nephrology, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland. raffaele.falciano@eoc.ch.
Elisa GrazianoDepartment of Internal Medicine and Nephrology, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland. elisa.graziano@eoc.ch.
Tommaso Rochat NegroDepartment of Internal Medicine and Nephrology, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland. Tommaso.RochatNegro@eoc.ch.
Luca GabuttiDepartment of Internal Medicine and Nephrology, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland. luca.gabutti@eoc.ch.ORCID 0000-0002-1929-6759
Ente Ospedaliero Cantonale · CHSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous experimental studies showed that increasing high-density lipoprotein cholesterol (HDL) cholesterol shortens cardiac ventricular repolarization and the QT interval corrected for heart rate (QTc). However, little is known about the epidemiological relationship between HDL and QTc. The potential antiarrhythmic effect of HDL cholesterol remains a speculative hypothesis. In this cross-sectional population based study in adults living in the Italian-speaking part of Switzerland, we aimed to explore the association between HDL cholesterol and the QTc interval in the general population. A total of 1202 subjects were screened. electrocardiogram (ECG) recordings, measurements of lipid parameters and other laboratory tests were performed. QTc was corrected using Bazett's (QTc

Indexed as

ECGepidemiological studyHDL cholesterolpopulation-based studyQTc intervalQTc prolongation risk

Identifiers

PMID31547597
PMCPMC6832837
OpenAlexW2974581001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.