ArticlePolymers2019
A Modular and Practical Synthesis of Zwitterionic Hydrogels through Sequential Amine-Epoxy "Click" Chemistry and N-Alkylation Reaction.
Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Counterion-Free Ionic Associating Polymers:Macromolecules · 2025Article
- Metal-Free Click-Chemistry: A Powerful Tool for Fabricating Hydrogels for Biomedical Applications.Bioconjugate chemistry · 2024Review
- Dual-reactive hydrogels functionalizable using "Huisgen click" and "Schiff base" reactions.Turkish journal of chemistry · 2023Article
- Article
- Electronic and Magnetic Properties of a Three-Arm Nonconjugated Open-Shell Macromolecule.ACS polymers Au · 2022Article
- Antibacterial properties of main-chain cationic polymers prepared through amine-epoxy 'Click' polymerization.RSC advances · 2020Article
- Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
In this work, the amine-epoxy "click" reaction is shown to be a valuable general tool in the synthesis of reactive hydrogels. The practicality of this reaction arises due to its catalyst-free nature, its operation in water, and commercial availability of a large variety of amine and epoxide molecules that can serve as hydrophilic network precursors. Therefore, hydrogels can be prepared in a modular fashion through a simple mixing of the precursors in water and used as produced (without requiring any post-synthesis purification step). The gelation behavior and final hydrogel properties depend upon the molecular weight of the precursors and can be changed as per the requirement. A post-synthesis modification through alkylation at the nitrogen atom of the newly formed β-hydroxyl amine linkages allows for functionalizing the hydrogels. For example, ring-opening reaction of cyclic sulfonic ester gives rise to surfaces with a zwitterionic character. Finally, the established gelation chemistry can be combined with soft lithography techniques such as micromolding in capillaries (MIMIC) to obtain hydrogel microstructures.
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Registered trials
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