Evidence map›Paper›PMID 31547327›Full record

ArticleMolecules (Basel, Switzerland)2019

Anti-Inflammatory Effect of Erinacine C on NO Production Through Down-Regulation of NF-κB and Activation of Nrf2-Mediated HO-1 in BV2 Microglial Cells Treated with LPS.

Li-Yu Wang, Chin-Shiu Huang, Yu-Hsuan Chen, Chin-Chu Chen, Chien-Chih Chen, Cheng-Hung Chuang

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Benefits, side effects, and uses ofFrontiers in nutrition · 2025
    Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Computational Analysis andCurrent medicinal chemistry · 2026
    Article
  9. Review
  10. Yamabushitake Mushroom (International journal of molecular sciences · 2025
    Article
  11. Lion's Mane Mushroom (Nutrients · 2025
    Review
  12. Article
  13. Review
  14. The Cerebral Protective Effect of Novel Erinacines fromAntioxidants (Basel, Switzerland) · 2024
    Article
  15. Article
  16. Article
  17. Neurotrophic and Neuroprotective Effects ofInternational journal of molecular sciences · 2023
    Review
  18. Article
  19. Article
  20. Bioactive Compounds from Medicinal Mushrooms.Advances in biochemical engineering/biotechnology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Li-Yu WangDepartment of Nutrition, Master Program of Biomedical Nutrition, Hungkuang University, Taichung City 43302, Taiwan. u99c206@gmail.com.
Chin-Shiu HuangDepartment of Food Nutrition and Health Biotechnology, Asia University, Taichung City 41354, Taiwan. cshuang@asia.edu.tw.ORCID 0000-0002-9895-9492
Yu-Hsuan ChenDepartment of Medical Laboratory Science and Technology, Central Taiwan University of Science and Technology, Taichung City 40601, Taiwan. yhchen2@ctust.edu.tw.
Chin-Chu ChenGrape King Bio Ltd., Taoyuan City 324, Taiwan. gkbioeng@grapeking.com.tw.
Chien-Chih ChenDepartment of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan City 33303, Taiwan. chen37426972@gmail.com.
Cheng-Hung ChuangDepartment of Nutrition, Master Program of Biomedical Nutrition, Hungkuang University, Taichung City 43302, Taiwan. chchuang@hk.edu.tw.ORCID 0000-0003-1963-1825
Chang Gung University of Science and Technology · TWHungkuang University · TWAsia University · TWCentral Taiwan University of Science and Technology · TW

Funding

Ministry of Science and Technology, Taiwan MOST 105-2622-B-241-001-CC2
6 · The paper itself

Abstract

Previous studies have revealed the anti-inflammatory and neuroprotective properties of

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalCell LineCell SurvivalDiterpenesHeme Oxygenase-1Interleukin-6LipopolysaccharidesMembrane ProteinsMiceMicrogliaNF-E2-Related Factor 2NF-kappa BNF-KappaB Inhibitor alphaNitric OxideNitric Oxide Synthase Type IIAnti-Inflammatory Agents, Non-SteroidalDiterpeneserinacine CHeme Oxygenase-1Hmox1 protein, mouseInterleukin-6interleukin-6, mouseLipopolysaccharidesMembrane ProteinsNfe2l2 protein, mouseNF-E2-Related Factor 2NF-kappa BNF-KappaB Inhibitor alphaNitric OxideNitric Oxide Synthase Type IINos2 protein, mouseTumor Necrosis Factor-alphaerinacine CHericium erinaceus myceliummicroglial cellsneuroinflammationnitric oxideproinflammatory cytokines

Identifiers

PMID31547327
PMCPMC6766924
OpenAlexW2972362691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.