Evidence map›Paper›PMID 31547324›Full record

ArticleMolecules (Basel, Switzerland)2019

Black Sorghum Phenolic Extract Regulates Expression of Genes Associated with Oxidative Stress and Inflammation in Human Endothelial Cells.

Nidhish Francis, Shiwangini Rao, Christopher Blanchard, Abishek Santhakumar

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 129 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nidhish FrancisSchool of Animal and Veterinary Sciences, Faculty of Science, Charles Sturt University, Wagga, NSW 2650, Australia. nfrancis@csu.edu.au.
Shiwangini RaoAustralian Research Council (ARC) Industrial Transformation Training Centre for Functional Grains, Graham Centre for Agricultural Innovation, Charles Sturt University, Wagga, NSW 2650, Australia. srao@csu.edu.au.
Christopher BlanchardAustralian Research Council (ARC) Industrial Transformation Training Centre for Functional Grains, Graham Centre for Agricultural Innovation, Charles Sturt University, Wagga, NSW 2650, Australia. cblanchard@csu.edu.au.
Abishek SanthakumarAustralian Research Council (ARC) Industrial Transformation Training Centre for Functional Grains, Graham Centre for Agricultural Innovation, Charles Sturt University, Wagga, NSW 2650, Australia. asanthakumar@csu.edu.au.ORCID 0000-0003-1836-5035
Australian Research Council · AU

Funding

Australian Research Council ICI40100027
6 · The paper itself

Abstract

Oxidative stress is one of the primary factors leading to endothelial dysfunction, a major underlying cause of vascular disorders. This study aims to understand the key signalling pathways regulated by sorghum (Shawaya short black 1 variety; characterised to be very high in its antioxidant activity) under oxidative stress in endothelial cells. Human umbilical vein endothelial cells (HUVECs) were pre-treated with non-cytotoxic concentrations of phenolic-rich black sorghum extract (BSE) prior to induction of oxidative stress using hydrogen peroxide (H

Indexed as

AntioxidantsApyraseGene Expression RegulationHeme Oxygenase-1HumansHuman Umbilical Vein Endothelial CellsInflammationInflammation MediatorsIntercellular Adhesion Molecule-1NADPH Oxidase 4Nitric Oxide Synthase Type IIIOxidative StressPhenolsPlant ExtractsSorghumAntioxidantsApyraseENTPD1 protein, humanHeme Oxygenase-1HMOX1 protein, humanICAM1 protein, humanInflammation MediatorsIntercellular Adhesion Molecule-1NADPH Oxidase 4Nitric Oxide Synthase Type IIINOS3 protein, humanNOX4 protein, humanPhenolsPlant Extractsblack sorghumgenesinflammationoxidative stresspolyphenols

Identifiers

PMID31547324
PMCPMC6767043
OpenAlexW2973025695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.