Evidence map›Paper›PMID 31547236›Full record

ReviewPathogens (Basel, Switzerland)2019

Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes.

Hussin A Rothan, Mukesh Kumar

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
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  3. Review
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  6. Review
  7. Cellular Immune Response in Horses After West Nile Neuroinvasive Disease.Animals : an open access journal from MDPI · 2025
    Article
  8. Article
  9. Article
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  11. Article
  12. Article
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  15. Review
  16. Article
  17. Article
  18. Article
  19. Metal-based complexes against SARS-CoV-2.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Review
  20. Development of Metal Complexes for Treatment of Coronaviruses.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hussin A RothanDepartment of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA 30303, USA. hrothan@gsu.edu.ORCID 0000-0002-7300-6388
Mukesh KumarDepartment of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA 30303, USA. mkumar8@gsu.edu.ORCID 0000-0003-0970-4875
Georgia State University · US

Funding

Defining the function of Schlafen4 in the pathogenesis of flavivirus encephalitisR21NS099838 · NINDS · UNIVERSITY OF HAWAII AT MANOA · PI KUMAR, MUKESH · 2016 to 2017
$424k
A Guinea Pig Model of Zika Virus DiseaseR21OD024896 · OD · UNIVERSITY OF HAWAII AT MANOA · PI KUMAR, MUKESH · 2017 to 2018
$402k
NIH HHS R21 OD024896NIH Office of the Director R21OD024896NINDS NIH HHS R21 NS099838NINDS NIH HHS R21NS099838
6 · The paper itself

Abstract

Flavivirus replication in host cells requires the formation of replication and assembly complexes on the cytoplasmic side of the endoplasmic reticulum (ER) membrane. These complexes consist of an ER membrane, viral proteins, and host proteins. Genome-wide investigations have identified a number of ER multiprotein complexes as vital factors for flavivirus replication. The detailed mechanisms of the role of ER complexes in flavivirus replication are still largely elusive. This review highlights the fact that the ER multiprotein complexes are crucial for the formation of flavivirus replication and assembly complexes, and the ER complexes could be considered as a target for developing successful broad-spectrum anti-flavivirus drugs.

Indexed as

endoplasmic reticulumflavivirushost factorsvirus replication complex

Identifiers

PMID31547236
PMCPMC6789530
OpenAlexW2972844769

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.