Evidence map›Paper›PMID 31547177›Full record

ArticleCancers2019

Methylation Assessment for the Prediction of Malignancy in Mediastinal Adenopathies Obtained by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Patients with Lung Cancer.

Virginia Leiro, Loretta De Chiara, Mar Rodríguez-Girondo, Maribel Botana-Rial, Diana Valverde, Manuel Núñez-Delgado, Alberto Fernández-Villar

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Unveiling molecular incomplete response (mIR)Cancer biology & medicine · 2026
    Article
  2. Detection ofMolecular and clinical oncology · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Mediastinal staging for non-small cell lung cancer.Translational lung cancer research · 2021
    Review
  9. Article
  10. Signaling pathways and clinical application of RASSF1A and SHOX2 in lung cancer.Journal of cancer research and clinical oncology · 2020
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Virginia LeiroPulmonary Department, Hospital Álvaro Cunqueiro, Vigo Health Area, 36312 Vigo, Spain.
Loretta De ChiaraDepartment of Biochemistry, Genetics and Immunology, Biomedical Research Center (CINBIO), University of Vigo, 36310 Vigo, Spain. Ldechiara@uvigo.es.
Mar Rodríguez-GirondoDepartment of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Maribel Botana-RialPulmonary Department, Hospital Álvaro Cunqueiro, Vigo Health Area, 36312 Vigo, Spain.
Diana ValverdeDepartment of Biochemistry, Genetics and Immunology, Biomedical Research Center (CINBIO), University of Vigo, 36310 Vigo, Spain.
Manuel Núñez-DelgadoPulmonary Department, Hospital Álvaro Cunqueiro, Vigo Health Area, 36312 Vigo, Spain.
Alberto Fernández-VillarPulmonary Department, Hospital Álvaro Cunqueiro, Vigo Health Area, 36312 Vigo, Spain.
University Hospital Complex Of Vigo · ESUniversidade de Vigo · ESLeiden University Medical Center · NL

Funding

Asociación Española de Endoscopia Respiratoria y Neumología Intervencionista Antonio Castella 2010Instituto de Salud Carlos III PI09/90385Instituto de Salud Carlos III RETIC-FIS-ISCIII RD09/0076/00011Xunta de Galicia 09CSA053905PF
6 · The paper itself

Abstract

The evaluation of mediastinal lymph nodes is critical for the correct staging of patients with lung cancer (LC). Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive technique for mediastinal staging, though unfortunately lymph node micrometastasis is often missed by cytological analysis. The aim of this study was to evaluate the predictive capacity of methylation biomarkers and provide a classification rule for predicting malignancy in false negative EBUS-TBNA samples. The study included 112 patients with a new or suspected diagnosis of LC that were referred to EBUS-TBNA. Methylation of

Indexed as

biomarkerbronchoscopydiagnosisDNA methylationendobronchial ultrasoundlung cancermediastinal and hilar lymph nodestaging

Identifiers

PMID31547177
PMCPMC6826358
OpenAlexW2973592818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.