Evidence map›Paper›PMID 31547149›Full record

ArticleToxins2019

The Mycotoxin Deoxynivalenol Significantly Alters the Function and Metabolism of Bovine Kidney Epithelial Cells In Vitro.

Jennifer R Bailey, Jonathan Breton, Gordana Panic, Tristan A Cogan, Michael Bailey, Jonathan R Swann, Michael R F Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Translational animal science · 2024
    Article
  5. First Characterization and Description ofJournal of fungi (Basel, Switzerland) · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jennifer R BaileyBristol Veterinary School, University of Bristol, Langford, Bristol BS40 5DU, UK. j.r.bailey@bristol.ac.uk.
Jonathan BretonDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. j.breton@imperial.ac.uk.
Gordana PanicDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. g.panic@imperial.ac.uk.ORCID 0000-0002-6423-3183
Tristan A CoganBristol Veterinary School, University of Bristol, Langford, Bristol BS40 5DU, UK. tristan.cogan@bristol.ac.uk.
Michael BaileyBristol Veterinary School, University of Bristol, Langford, Bristol BS40 5DU, UK. mick.bailey@bristol.ac.uk.
Jonathan R SwannDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. j.swann@imperial.ac.uk.ORCID 0000-0002-6485-4529
Michael R F LeeBristol Veterinary School, University of Bristol, Langford, Bristol BS40 5DU, UK. michael.lee@rothamsted.ac.uk.
Imperial College London · GBUniversity of Bristol · GBRothamsted Research · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M006409/1
6 · The paper itself

Abstract

Bovine mycotoxicosis is a disorder caused by the ingestion of fungal toxins. It is associated with chronic signs, such as reduced growth rate and milk yield, and causes significant economic cost to the dairy industry. The mycotoxins deoxynivalenol (DON), zearalenone (ZEN), and fumonisin B1 (FB1) are commonly found in grain fed to cattle. Patulin (PA) is a common grass silage contaminant but is also found in grain. The effects of these mycotoxins on cellular function at low concentrations are not well understood. Using Madin-Darby bovine kidney cells we evaluated the cellular response to these mycotoxins, measuring cytotoxicity, de novo protein synthesis, cell proliferation, cell cycle analysis, and also metabolic profiling by

Indexed as

AnimalsCattleCell CycleCell ProliferationCells, CulturedEpithelial CellsKidneyProtein BiosynthesisTrichothecenesdeoxynivalenolTrichothecenescell cycle arrestmetabolic profilingmycotoxicosisprotein synthesis

Identifiers

PMID31547149
PMCPMC6832441
OpenAlexW2973260694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.