Evidence map›Paper›PMID 31547135›Full record

ReviewViruses2019

Hepatitis E Virus Entry.

Xin Yin, Zongdi Feng

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Cell binding tropism of rat hepatitis E virus is a pivotal determinant of its zoonotic transmission to humans.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Structural aspects of hepatitis E virus.Archives of virology · 2022
    Review
  16. Review
  17. Virus-Associated Nephropathies: A Narrative Review.International journal of molecular sciences · 2022
    Review
  18. Development ofMolecular pharmaceutics · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xin YinCenter for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA. xyin@sbpdiscovery.org.ORCID 0000-0003-2357-6718
Zongdi FengCenter for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA. zongdi.feng@nationwidechildrens.org.ORCID 0000-0001-7913-1027
Nationwide Children's Hospital · US

Funding

Mechanism for spread of a quasi-enveloped hepatotropic virusR01AI139511 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI FENG, ZONGDI · 2018 to 2022
$2.2M
Immunomodulation by hepatitis E virus free antigenR21AI137912 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI FENG, ZONGDI · 2018 to 2019
$418k
NIAID NIH HHS R01 AI139511NIAID NIH HHS R21 AI137912
6 · The paper itself

Abstract

Hepatitis E virus (HEV) infection is a major cause of acute hepatitis worldwide. It is transmitted enterically but replicates in the liver. Recent studies indicate that HEV exists in two forms: naked, nonenveloped virions that are shed into feces to mediate inter-host transmission, and membrane-cloaked, quasienveloped virions that circulate in the bloodstream to mediate virus spread within a host. Both virion types are infectious, but differ in the way they infect cells. Elucidating the entry mechanism for both virion types is essential to understand HEV biology and pathogenesis, and is relevant to the development of treatments and preventions for HEV. This review summarizes the current understanding of the cell entry mechanism for these two HEV virion types.

Indexed as

Virus InternalizationHepatitis EHepatitis E virusHumansLysosomesReceptors, VirusVirionVirus UncoatingReceptors, Viruslysosomal acid lipaseNPC1quasienveloped virusreceptor

Identifiers

PMID31547135
PMCPMC6832200
OpenAlexW2974091288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.