Evidence map›Paper›PMID 31547131›Full record

ReviewVaccines2019

Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family.

Shu Hui Wong, Alagie Jassey, Jonathan Y Wang, Wei-Cheng Wang, Ching-Hsuan Liu, Liang-Tzung Lin

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Review
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  8. Immunity, virus evolution, and effectiveness of SARS-CoV-2 vaccines.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021
    Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Shu Hui WongInternational Master Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. m142107001@tmu.edu.tw.
Alagie JasseyInternational Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. d142105007@tmu.edu.tw.
Jonathan Y WangInternational Master Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. m142107002@tmu.edu.tw.ORCID 0000-0002-5088-9026
Wei-Cheng WangGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. m120107011@tmu.edu.tw.
Ching-Hsuan LiuGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. d119107007@tmu.edu.tw.
Liang-Tzung LinGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. ltlin@tmu.edu.tw.
Taipei Medical University · TWDalhousie University · CAMontreal Clinical Research Institute · CA

Funding

Ministry of Science and Technology, Taiwan MOST107-2320-B-038-034-MY3
6 · The paper itself

Abstract

Viruses in the Flaviviridae family are important human and animal pathogens that impose serious threats to global public health. This family of viruses includes emerging and re-emerging viruses, most of which are transmitted by infected mosquito or tick bites. Currently, there is no protective vaccine or effective antiviral treatment against the majority of these viruses, and due to their growing spread, several strategies have been employed to manufacture prophylactic vaccines against these infectious agents including virus-like particle (VLP) subunit vaccines. VLPs are genomeless viral particles that resemble authentic viruses and contain critical repetitive conformational structures on their surface that can trigger the induction of both humoral and cellular responses, making them safe and ideal vaccine candidates against these viruses. In this review, we focus on the potential of the VLP platform in the current vaccine development against the medically important viruses in the Flaviviridae family.

Indexed as

Flaviviridaeimmunogenicityvaccinesvirus-like particles

Identifiers

PMID31547131
PMCPMC6963367
OpenAlexW2974740310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.