Evidence map›Paper›PMID 31547109›Full record

SynthesisInternational journal of molecular sciences2019

Diagnostic Performance and Prognostic Value of PET/CT with Different Tracers for Brain Tumors: A Systematic Review of Published Meta-Analyses.

Giorgio Treglia, Barbara Muoio, Gianluca Trevisi, Maria Vittoria Mattoli, Domenico Albano, Francesco Bertagna, Luca Giovanella

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04626206 (Multi-paramEtric Imaging to Assess Treatment REsponse After Stereotactic Radiosurgery of Brain Metastases), which is not on this map. Cited by 53 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 4 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04626206 unknown statusnot on this mapstarted 2020, after this paper: background citation

Multi-paramEtric Imaging to Assess Treatment REsponse After Stereotactic Radiosurgery of Brain Metastases

TypeobservationalSponsorRoyal Marsden NHS Foundation TrustRan2020 to 2021Enrolled12ConditionsBrain Metastases, Adult
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 4 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Tumefactive demyelinating disorders as neoplasm mimics: description of a typical case and literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  7. Comparative Insights intoMolecular imaging and radionuclide therapy · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Recent Update on PET/CT Radiotracers for Imaging Cerebral Glioma.Nuclear medicine and molecular imaging · 2024
    Review
  14. Diagnostic Accuracy of PET withDiagnostics (Basel, Switzerland) · 2023
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. A dataset of [Data in brief · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Giorgio TregliaClinic of Nuclear Medicine and PET/CT Center, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, CH-6500 Bellinzona, Switzerland. giorgio.treglia@eoc.ch.ORCID 0000-0001-9808-780X
Barbara MuoioClinic of Medical Oncology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, CH-6500 Bellinzona, Switzerland. barbara.muoio@eoc.ch.
Gianluca TrevisiNeurosurgical Unit, Presidio Ospedaliero Santo Spirito, IT-65124 Pescara, Italy. trevisi.gianluca@gmail.com.
Maria Vittoria MattoliDepartment of Neurosciences, Imaging and Clinical Sciences, "G. D'Annunzio" University, IT-66100 Chieti, Italy. mvittoriamattoli@yahoo.it.
Domenico AlbanoDepartment of Nuclear Medicine, Spedali Civili of Brescia and University of Brescia, IT-25123 Brescia, Italy. doalba87@libero.it.
Francesco BertagnaDepartment of Nuclear Medicine, Spedali Civili of Brescia and University of Brescia, IT-25123 Brescia, Italy. francesco.bertagna@unibs.it.
Luca GiovanellaClinic of Nuclear Medicine and PET/CT Center, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, CH-6500 Bellinzona, Switzerland. luca.giovanella@eoc.ch.ORCID 0000-0003-0230-0974
Ente Ospedaliero Cantonale · CHUniversity of Brescia · ITPresidio Ospedaliero · ITUniversity of Chieti-Pescara · ITUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral meta-analyses reporting data on the diagnostic performance or prognostic value of positron emission tomography (PET) with different tracers in detecting brain tumors have been published so far. This review article was written to summarize the evidence-based data in these settings.

methodsWe have performed a comprehensive literature search of meta-analyses published in the Cochrane library and PubMed/Medline databases (from inception through July 2019) about the diagnostic performance or prognostic value of PET with different tracers in patients with brain tumors.

resultsWe have summarized the results of 24 retrieved meta-analyses on the use of PET or PET/computed tomography (CT) with different tracers in brain tumors. The tracers included were: fluorine-18 fluorodeoxyglucose (

conclusionsEvidence-based data showed a good diagnostic performance for some PET tracers in specific indications and significant prognostic value in brain tumors.

Indexed as

Positron Emission Tomography Computed TomographyBrain NeoplasmsHumansPrognosisRadioactive TracersRadiopharmaceuticalsRadioactive TracersRadiopharmaceuticalsbrain metastasesbrain tumorsdiagnostic performancegliomameta-analysisPETpositron emission tomographyprognosis

Identifiers

PMID31547109
PMCPMC6802483
OpenAlexW2973697549

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.