Evidence map›Paper›PMID 31547053›Full record

ArticleAntibiotics (Basel, Switzerland)2019

Using Colistin as a Trojan Horse: Inactivation of Gram-Negative Bacteria with Chlorophyllin.

Peter Richter, Marcus Krüger, Binod Prasad, Susanne Gastiger, Mona Bodenschatz, Florian Wieder, Andreas Burkovski, Walter Geißdörfer, Michael Lebert, Sebastian M Strauch

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Molecular Evaluation of Expression Changes in Genes Associated With Colistin Resistance and Virulence Development inThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  4. Article
  5. Photodynamic Activity of Chlorophyllin and Polyethylenimine onInternational journal of molecular sciences · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Peter RichterCell Biology Division, Department of Biology, Friedrich-Alexander University Erlangen-Nuremberg, Staudtstraße 5, 91058 Erlangen, Germany. peter.richter@fau.de.
Marcus KrügerClinic for Plastic, Aesthetic and Hand Surgery, Otto von Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany. marcus.krueger@med.ovgu.de.
Binod PrasadCell Biology Division, Department of Biology, Friedrich-Alexander University Erlangen-Nuremberg, Staudtstraße 5, 91058 Erlangen, Germany. binod.prasad@fau.de.
Susanne GastigerMicrobiology Division, Department of Biology, Friedrich-Alexander University Erlangen-Nuremberg, Staudtstraße 5, 91058 Erlangen, Germany. susanne.gastiger@fau.de.
Mona BodenschatzMicrobiology Division, Department of Biology, Friedrich-Alexander University Erlangen-Nuremberg, Staudtstraße 5, 91058 Erlangen, Germany. mona.bodenschatz@fau.de.
Florian WiederCell Biology Division, Department of Biology, Friedrich-Alexander University Erlangen-Nuremberg, Staudtstraße 5, 91058 Erlangen, Germany. flo_20@hotmail.com.
Andreas BurkovskiMicrobiology Division, Department of Biology, Friedrich-Alexander University Erlangen-Nuremberg, Staudtstraße 5, 91058 Erlangen, Germany. andreas.burkovski@fau.de.
Walter GeißdörferMicrobiological Diagnostics, Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen, Wasserturmstraße 3/5, 91054 Erlangen, Germany. walter.geissdoerfer@uk-erlangen.de.
Michael LebertCell Biology Division, Department of Biology, Friedrich-Alexander University Erlangen-Nuremberg, Staudtstraße 5, 91058 Erlangen, Germany. michael.lebert@fau.de.
Sebastian M StrauchPostgraduate Program in Health and Environment, University of Joinville Region, Rua Paulo Malschitzki, 10, Joinville 89219-710, Brazil. sebastian.michael@univille.br.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEOtto-von-Guericke-Universität Magdeburg · DEUniversidade da Região de Joinville · BRUniversitätsklinikum Erlangen · DE

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior n/aDeutsches Zentrum für Luft- und Raumfahrt 50WB1128Staedtler Stiftung n/a
6 · The paper itself

Abstract

Colistin (polymyxin E) is a membrane-destabilizing antibiotic used against Gram-negative bacteria. We have recently reported that the outer membrane prevents the uptake of antibacterial chlorophyllin into Gram-negative cells. In this study, we used sub-toxic concentrations of colistin to weaken this barrier for a combination treatment of

Indexed as

antibiotic resistancebacteriachlorophyllcombination therapymcr-1photosensitization

Identifiers

PMID31547053
PMCPMC6963628
OpenAlexW2973257861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.