Evidence map›Paper›PMID 31547012›Full record

ArticlePharmaceuticals (Basel, Switzerland)2019

Tamoxifen Protects from Vesicular Stomatitis Virus Infection.

Lamin B Cham, Sarah-Kim Friedrich, Tom Adomati, Hilal Bhat, Maximilian Schiller, Michael Bergerhausen, Thamer Hamdan, Fanghui Li, Yara Maria Machlah, Murtaza Ali and 4 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. CD47 monoclonal antibodies differ in their capacity to induce immune response.European journal of microbiology & immunology · 2025
    Article
  2. Review
  3. Preparing for the next viral threat with broad-spectrum antivirals.The Journal of clinical investigation · 2023
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Could Estrogen Protect Women From COVID-19?Journal of clinical medicine research · 2020
    Review
  9. Article
  10. Role of Autophagy in Lung Inflammation.Frontiers in immunology · 2020
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Lamin B ChamInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. laminbcham@gmail.com.
Sarah-Kim FriedrichInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. Sarah-KimFriedrich@gmx.net.
Tom AdomatiInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. Tom.Adomati@uk-essen.de.
Hilal BhatInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. bhathilal673@gmail.com.
Maximilian SchillerInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. Maximilian-Schiller@web.de.
Michael BergerhausenInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. michael.bergerhausen@gmail.com.
Thamer HamdanInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. tamer_balaawi@yahoo.com.
Fanghui LiInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. fanghui.li@uni-due.de.
Yara Maria MachlahInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. yaramachlah@yahoo.com.
Murtaza AliInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. Murtaza142426@st.jmi.ac.in.
Vikas DuhanInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. Duhan.Vikas@uk-essen.de.
Karl Sebastian LangInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. KarlSebastian.Lang@uk-essen.de.
Justa Friebus-KardashInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. Justa.Friebus-Kardash@uk-essen.de.
Judith BezgovsekInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. Judith.Lang@uk-essen.de.
University of Duisburg-Essen · DE

Funding

Deutsche Forschungsgemeinschaft RTG1949
6 · The paper itself

Abstract

backgroundTamoxifen (TAM) is an estrogen-receptor antagonist, widely used in the adjuvant treatment of early stage estrogen-sensitive breast cancer. Several studies have revealed new biological targets of TAM that mediate the estrogen receptor independent activities of the drug. Recently, the antiviral activity of TAM on replication of human immunodeficiency virus (HIV), hepatitis C virus (HCV) and Herpes simplex virus (HSV-1) in vitro was described. In the current study, we aimed to investigate the effect of TAM on infection with vesicular stomatitis virus (VSV).

methodsVero cells were treated with different concentrations of TAM for 24 h and then infected with VSV. Additionally, C57BL/6 mice were pretreated with 4 mg TAM, one day and three days before infection with VSV.

Indexed as

antiviral activityinterferontamoxifen (TAM)vesicular stomatitis virus (VSV) infection

Identifiers

PMID31547012
PMCPMC6958322
OpenAlexW2974053186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.