ReviewNutrients2019
Face-to-Face and Digital Multidomain Lifestyle Interventions to Enhance Cognitive Reserve and Reduce Risk of Alzheimer's Disease and Related Dementias: A Review of Completed and Prospective Studies.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07668440 (Preliminary Assessment of the Effects, Usability, Satisfaction, Barriers, and Benefits of a Remote, Multidomain Intervention Supported by a Website to Prevent Cognitive Decline in Older Adults), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preliminary Assessment of the Effects, Usability, Satisfaction, Barriers, and Benefits of a Remote, Multidomain Intervention Supported by a Website to Prevent Cognitive Decline in Older Adults
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is Stress an Overlooked Risk Factor for Dementia? A Systematic Review from a Lifespan Developmental Perspective.Prevention science : the official journal of the Society for Prevention Research · 2023Pooled it
- Efficacy of a Mobile-Based Multidomain Intervention to Improve Cognitive Function and Health-Related Outcomes Among Older Korean Adults with Subjective Cognitive Decline.Journal of Alzheimer's disease : JAD · 2023Trial
- Cognitive reserve in seven-year-old children at familial high risk of schizophrenia or bipolar disorder.European child & adolescent psychiatry · 2026Article
- Digital Technology in Cognitive Decline: Bibliometric and Visualization Study.Current Alzheimer research · 2026Review
- Exercise training-induced benefits for Alzheimer's disease are associated with modulation of the BDNF-TrkB signaling complex.Scientific reports · 2025Article
- The role of structured remembrance programs in supporting the wellbeing of pediatric health workers.Palliative & supportive care · 2025Article
- Transforming long-term adjunctive therapy for cognitive impairment: the role of multimodal self-adaptive digital medicine.Frontiers in neurology · 2025Article
- Digital Multidomain Lifestyle Intervention for Community-Dwelling Older Adults: A Mixed Methods Evaluation.International journal of public health · 2025Article
- ADL+: A Digital Toolkit for Multidomain Cognitive, Physical, and Nutritional Interventions to Prevent Cognitive Decline in Community-Dwelling Older Adults.International journal of environmental research and public health · 2024Article
- The efficacy of a mobile-based multidomain program on cognitive functioning of residents in assisted living facilities.Public health in practice (Oxford, England) · 2024Article
- Technology that CARES: Enhancing dementia care through everyday technologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Initial Perspectives From Rural-Residing Adults on a Digital Cognitive Health Coaching Intervention: Exploratory Qualitative Analysis.JMIR formative research · 2024Article
- Study design and methods: U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Second language learning in older adults modulates Stroop task performance and brain activation.Frontiers in aging neuroscience · 2024Article
- A Scoping Survey to Inform Design of Digital Dementia Risk Reduction Interventions for Adults Concerned about their Cognitive Health.Journal of Alzheimer's disease reports · 2024Article
- Healthy brain aging and delayed dementia in Texas rural elderly.Ageing research reviews · 2023Review
- Article
- The effect of a digital health coaching and health education protocol on cognition in adults at-risk for Alzheimer's.GeroScience · 2023Article
- 3D genome-selected microRNAs to improve Alzheimer's disease prediction.Frontiers in neurology · 2023Article
- Effects of multidomain lifestyle interventions on cognitive decline and Alzheimer's disease prevention: A literature review and future recommendations.Cerebral circulation - cognition and behavior · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, there is no pharmaceutical intervention to treat or delay pathological cognitive decline or Alzheimer's disease and related dementias (ADRD). Multidomain lifestyle interventions are increasingly being studied as a non-pharmacological solution to enhance cognitive reserve, maintain cognition, and reduce the risk of or delay ADRD. Review of completed and prospective face-to-face (FTF) and digital multidomain interventions provides an opportunity to compare studies and informs future interventions and study design.
methodsElectronic databases (PubMed, PsycINFO, clinicaltrials.gov and NIH RePORTER) were searched for multidomain lifestyle programs. Studies were included if the program (1) included a control group, (2) included at least 3 interventions, (3) were at least 6 months in duration, and (4) included measurement of cognitive performance as an outcome.
resultsIn total, 17 multidomain lifestyle programs aimed at enhancing cognitive reserve and reducing risk of ADRD were found. Thirteen programs are FTF in intervention delivery, with 3 FTF programs replicating the FINGER protocol as part of the World Wide Fingers Consortium. Four programs are delivered digitally (website, Web application, or mobile app). Program characteristics (e.g., target population, duration, frequency, outcomes, and availability) and results of completed and prospective studies are reviewed and discussed.
conclusionThis review updates and discusses completed and current multidomain lifestyle interventions aimed at enhancing cognitive reserve and reducing risk of ADRD. A growing number of international studies are investigating the efficacy and utility of these programs in both FTF and digital contexts. While a diversity of study designs and interventions exist, FTF and digital programs that build upon the foundational work of the FINGER protocol have significant potential to enhance cognitive reserve and reduce risk of ADRD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.