Evidence map›Paper›PMID 31546936›Full record

ArticleVaccines2019

In Vivo Administration of Recombinant Human Granulocyte Colony-Stimulating Factor Increases the Immune Effectiveness of Dendritic Cell-Based Cancer Vaccination.

Shigetaka Shimodaira, Ryu Yanagisawa, Terutsugu Koya, Koichi Hirabayashi, Yumiko Higuchi, Takuya Sakamoto, Misa Togi, Tomohisa Kato, Takashi Kobayashi, Tomonobu Koizumi and 2 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Shigetaka ShimodairaDepartment of Regenerative Medicine, Kanazawa Medical University, Uchinada, Kahoku 920-0293, Japan. shimodai@kanazawa-med.ac.jp.
Ryu YanagisawaCenter for Advanced Cell Therapy, Shinshu University Hospital, Matsumoto 390-8621, Japan. ryu@shinshu-u.ac.jp.
Terutsugu KoyaDepartment of Regenerative Medicine, Kanazawa Medical University, Uchinada, Kahoku 920-0293, Japan. koya@kanazawa-med.ac.jp.
Koichi HirabayashiCenter for Advanced Cell Therapy, Shinshu University Hospital, Matsumoto 390-8621, Japan. kohira@shinshu-u.ac.jp.
Yumiko HiguchiDepartment of Clinical Laboratory Sciences, Shinshu University School of Medicine, Matsumoto 390-8621, Japan. sasa0922@shinshu-u.ac.jp.
Takuya SakamotoDepartment of Regenerative Medicine, Kanazawa Medical University, Uchinada, Kahoku 920-0293, Japan. taku0731@kanazawa-med.ac.jp.ORCID 0000-0003-2519-4510
Misa TogiDepartment of Regenerative Medicine, Kanazawa Medical University, Uchinada, Kahoku 920-0293, Japan. m-togi@kanazawa-med.ac.jp.ORCID 0000-0002-7424-4548
Tomohisa KatoDepartment of Regenerative Medicine, Kanazawa Medical University, Uchinada, Kahoku 920-0293, Japan.
Takashi KobayashiShinshu Cancer Center, Shinshu University Hospital, Matsumoto 390-8621, Japan. takob@shinshu-u.ac.jp.
Tomonobu KoizumiShinshu Cancer Center, Shinshu University Hospital, Matsumoto 390-8621, Japan. tomonobu@shinshu-u.ac.jp.
Shigeo KoidoDepartment of Gastroenterology and Hepatology, The Jikei University School of Medicine, Kashiwa, Chiba 277-8567, Japan. shigeo_koido@jikei.ac.jp.ORCID 0000-0003-0397-4348
Haruo SugiyamaDepartment of Cancer Immunology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. sugiyama@sahs.med.osaka-u.ac.jp.
Kanazawa Medical University · JPShinshu University Hospital · JPJikei University School of Medicine · JPShinshu University · JPThe University of Osaka · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significant recent advances in cancer immunotherapeutics include the vaccination of cancer patients with tumor antigen-associated peptide-pulsed dendritic cells (DCs). DC vaccines with homogeneous, mature, and functional activities are required to achieve effective acquired immunity; however, the yield of autologous monocyte-derived DCs varies in each patient. Priming with a low dose of recombinant human granulocyte colony-stimulating factor (rhG-CSF) 16-18 h prior to apheresis resulted in 50% more harvested monocytes, with a significant increase in the ratio of CD11c

Indexed as

acquired immunitycancer vaccinedendritic cellgranulocyte colony-stimulating factortetramer analysisvaccination

Identifiers

PMID31546936
PMCPMC6789603
OpenAlexW2973648598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.