Selectively Charged and Zwitterionic Analogues of the Smallest Immunogenic Structure of Streptococcus Pneumoniae Type 14.

Tiziana Gragnani, Doretta Cuffaro, Silvia Fallarini, Grazia Lombardi, Felicia D'Andrea, Lorenzo Guazzelli

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Developments in Carbohydrate-Based Metzincin Inhibitors.Pharmaceuticals (Basel, Switzerland) · 2020
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tiziana GragnaniDipartimento di Farmacia, University of Pisa, Via Bonanno 6/33, 56126 Pisa, Italy. mastgragnani@inwind.it.

Doretta CuffaroDipartimento di Farmacia, University of Pisa, Via Bonanno 6/33, 56126 Pisa, Italy. doretta.cuffaro@for.unipi.it.

Silvia FallariniDipartimento di Scienze del Farmaco, University of Piemonte Orientale Amedeo Avogadro, Largo Donegani 2, 28100 Novara, Italy. silvia.fallarini@uniupo.it.

Grazia LombardiDipartimento di Scienze del Farmaco, University of Piemonte Orientale Amedeo Avogadro, Largo Donegani 2, 28100 Novara, Italy. grazia.lombardi@uniupo.it.

Felicia D'AndreaDipartimento di Farmacia, University of Pisa, Via Bonanno 6/33, 56126 Pisa, Italy. felicia.dandrea@unipi.it.

Lorenzo GuazzelliDipartimento di Farmacia, University of Pisa, Via Bonanno 6/33, 56126 Pisa, Italy. lorenzo.guazzelli@unipi.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zwitterionic polysaccharides (ZPs) have been shown in recent years to display peculiar immunological properties, thus attracting the interest of the carbohydrate research community. To fully elucidate the mechanisms underlying these properties and exploit the potential of this kind of structures, in depth studies are still required. In this context, the preparation of two cationic, an anionic, as well as two zwitterionic tetrasaccharide analogues of the smallest immunogenic structure of

Indexed as

AnimalsMiceMolecular ConformationPolysaccharides, BacterialRAW 264.7 CellsStreptococcus pneumoniaePolysaccharides, Bacterialcompetitive ELISAStreptococcus pneumoniae type 14zwitterionic analogues

Identifiers

PMID31546911

DOI10.3390/molecules24183414

PMCPMC6767069

What OpenQuestion holds

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