ArticleNutrients2019
Dietary Acid Load: A Novel Nutritional Target in Overweight/Obese Children with Asthma?
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- The Effect of Dietary Acid Load on Cardiometabolic Risk, Psychological Resilience and Sleep Quality in Adolescents with ObesityJournal of clinical research in pediatric endocrinology · 2025Article
- Effects of higher dietary acid load: a narrative review with special emphasis in children.Pediatric nephrology (Berlin, Germany) · 2025Review
- Article
- Article
- Dietary acid load and esophageal cancer risk: A case-control study.Thoracic cancer · 2022Article
- The relationship between dietary acid load and intensity of musculoskeletal pain condition: A population-based study.Food science & nutrition · 2022Article
- Dietary Acid Load Modulation of Asthma-Related miRNAs in the Exhaled Breath Condensate of Children.Nutrients · 2022Article
- The Influence of Eating at Home on Dietary Diversity and Airway Inflammation in Portuguese School-Aged Children.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Obesity has been repeatedly linked to asthma, and several potential mechanisms have been proposed in the etiologies of the obese-asthma phenotype. Considering that lungs play an important role in systemic pH and acid-base regulation, are a key organ in asthma development, and that nutritional inadequacy of several nutrients and high dietary acid load can affect airway inflammation and reactivity, we aimed to test the hypothesis that dietary acid load may be associated with asthma in children. Data on 699 children (52% females), aged 7-12 years, were analyzed. Anthropometric measurements were performed to assess body mass index. Dietary acid load was calculated using potential renal acid load (PRAL) equations from a 24 h dietary recall administrated to children. Adjusted PRAL for total energy intake was applied with the use of the residual method. Lung function and airway reversibility were assessed with spirometry. Asthma was defined by a positive bronchodilation or self-reported medical diagnosis with reported symptoms (wheezing, dyspnea, or dry cough) in the past 12 months. After adjustment for energy intake, sex, age, parent's education level, and physical activity, positive and significant associations were found between asthma and PRAL [odds ratio (OR) = 1.953, 95% CI = 1.024, 3.730) in overweight/obese children. Our findings suggest that dietary acid load might be a possible mechanism in overweight/obese-asthma phenotype development.
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Registered trials
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