Evidence map›Paper›PMID 31546752›Full record

ArticleMolecules (Basel, Switzerland)2019

A Monte Carlo Method for Determining the Response Relationship between Two Commonly Used Detectors to Indirectly Measure Alpha Particle Radiation Activity.

Christopher J Tichacek, Mikalai M Budzevich, Thaddeus J Wadas, David L Morse, Eduardo G Moros

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Development of [EJNMMI radiopharmacy and chemistry · 2023
    Article
  3. Article
  4. Pharmaceutics · 2023
    Review
  5. Article
  6. Preclinical evaluation of [European journal of nuclear medicine and molecular imaging · 2021
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Christopher J TichacekDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. Christopher.Tichacek@moffitt.org.
Mikalai M BudzevichSmall Animal Imaging Laboratory, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. Mikalai.Budzevich@moffitt.org.
Thaddeus J WadasDepartment of Cancer Biology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA. twadas@wakehealth.edu.ORCID 0000-0002-9913-0336
David L MorseDepartment of Cancer Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. David.Morse@moffitt.org.ORCID 0000-0002-6006-7528
Eduardo G MorosDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. Eduardo.Moros@moffitt.org.
University of South Florida · USMoffitt Cancer Center · USWake Forest University · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
H. Lee Moffitt Cancer Center and Research Institute P30-CA076292Melanoma Research Alliance 402889NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

Using targeted ligands to deliver alpha-emitting radionuclides directly to tumor cells has become a promising therapeutic strategy. To calculate the radiation dose to patients, activities of parent and daughter radionuclides must be measured. Scintillation detectors can be used to quantify these activities; however, activities found in pre-clinical and clinical studies can exceed their optimal performance range. Therefore, a method of correcting scintillation detector measurements at higher activities was developed using Monte Carlo modeling. Because there are currently no National Institute of Standards and Technology traceable Actinium-225 (

Indexed as

Alpha ParticlesMonte Carlo MethodRadiationGamma RaysNormal DistributionActinium-225alpha particle therapyMonte Carloradiation detection

Identifiers

PMID31546752
PMCPMC6767018
OpenAlexW2973365840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.