Evidence map›Paper›PMID 31546723›Full record

ArticleViruses2019

A New Cell Model for Investigating Prion Strain Selection and Adaptation.

Alexandra Philiastides, Juan Manuel Ribes, Daniel Chun-Mun Yip, Christian Schmidt, Iryna Benilova, Peter-Christian Klöhn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexandra PhiliastidesMRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London W1W7FF, UK. a.philiastides@prion.ucl.ac.uk.
Juan Manuel RibesMRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London W1W7FF, UK. j.ribes@prion.ucl.ac.uk.
Daniel Chun-Mun YipMRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London W1W7FF, UK. d.yip@synthace.com.
Christian SchmidtMRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London W1W7FF, UK. c.schmidt@prion.ucl.ac.uk.
Iryna BenilovaMRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London W1W7FF, UK. I.Benilova@prion.ucl.ac.uk.
Peter-Christian KlöhnMRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London W1W7FF, UK. p.kloehn@prion.ucl.ac.uk.

Funding

Medical Research Council MC_U123182016Medical Research Council MC_UP_1004/1Medical Research Council MC_UU_00024/2Medical Research Council MC_UU_00024/4
6 · The paper itself

Abstract

Prion diseases are fatal neurodegenerative diseases that affect humans and animals. Prion strains, conformational variants of misfolded prion proteins, are associated with distinct clinical and pathological phenotypes. Host-strain interactions result in the selective damage of distinct brain areas and they are responsible for strain selection and/or adaptation, but the underlying molecular mechanisms are unknown. Prion strains can be distinguished by their cell tropism

Indexed as

Models, BiologicalAnimalsAstrocytesCell LineCells, CulturedHost SpecificityMicePrion DiseasesPrionsPrPSc ProteinsPrionsPrPSc Proteinsadaptationastrocytesneurodegenerationneuronsprion propagationprionsprion strainsselective neuronal vulnerability

Identifiers

PMID31546723
PMCPMC6832381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.