Evidence map›Paper›PMID 31546372›Full record

ReviewMaterials science & engineering. C, Materials for biological applications2019

Electrospray for generation of drug delivery and vaccine particles applied in vitro and in vivo.

Rebeca T Steipel, Matthew D Gallovic, Cole J Batty, Eric M Bachelder, Kristy M Ainslie

Open access · greenAbstract readReview
In one paragraph

Review in Materials science & engineering. C, Materials for biological applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 90 citations in OpenAlex.

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  10. Micro and nanotechnologies: The little formulations that could.Bioengineering & translational medicine · 2023
    Review
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  15. A guide to oral vaccination: Highlighting electrospraying as a promising manufacturing technique toward a successful oral vaccine development.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rebeca T SteipelDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA.
Matthew D GallovicIMMvention Therapeutix, Durham, NC, USA.
Cole J BattyDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA.
Eric M BachelderDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA.
Kristy M AinslieDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill/North Carolina State University, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, USA. Electronic address: ainsliek@email.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Micro-Particle Delivery of a Potent Intracellular Adjuvant for a Universal Flu VaccineR01AI141333 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BACHELDER, ERIC, TING, JENNY P · 2019 to 2023
$5.9M
Biomaterials to study tolerance immune induction kineticsR01AI137525 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AINSLIE, KRISTY M · 2018 to 2022
$1.9M
Advancing Formulation of STING agonist for Universal Flu VaccineR41AI140795 · NIAID · IMMVENTION THERAPEUTIX, INC. · PI AINSLIE, KRISTY M, GOYAL, ANIL KUMAR · 2018 to 2018
$277k
NIAID NIH HHS R01 AI137525NIAID NIH HHS R01 AI141333NIAID NIH HHS R41 AI140795
6 · The paper itself

Abstract

Also known as electrospray, electrohydrodynamic atomization has been used extensively in the last 15 years to develop polymer-based particles for drug delivery in cell and animal models. More recently, novel core-shell, multi-axial, and other electrospray particles have been developed from an array of polymers for a variety of biomedical applications. This review focuses on electrospray as a novel method of particle fabrication for drug delivery, specifically highlighting the applications of these particle systems in cell culture and animal models while also discussing polymers used for particle fabrication. Applications of electrospray particles to treat glioma, ovarian cancer, and breast cancer are reviewed. Additionally, delivery of antibiotics, gene therapy, and bacterial cells formulated in electrospray particles is discussed. Finally, vaccines as well as drug eluting particles for differentiation of stem cells and tissue engineering are highlighted. The article concludes with a discussion of where the future of electrospray technology can go to strengthen its foothold in the biomedical field.

Indexed as

AnimalsDelayed-Action PreparationsDrug Delivery SystemsHumansPolymersVaccinesDelayed-Action PreparationsPolymersVaccinesAntimicrobialCancerCell deliveryGene deliveryPolymeric particlesTissue engineeringVaccines

Identifiers

PMID31546372
PMCPMC10366704
OpenAlexW2968201145

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.