Evidence map›Paper›PMID 31545995›Full record

ArticleNeurochemistry international2019

Selectivity of (±)-citalopram at nicotinic acetylcholine receptors and different inhibitory mechanisms between habenular α3β4* and α9α10 subtypes.

Hugo R Arias, Xiao-Tao Jin, Sofía Gallino, Can Peng, Dominik Feuerbach, Jesús García-Colunga, Ana Belén Elgoyhen, Ryan M Drenan, Marcelo O Ortells

Open access · greenAbstract read
In one paragraph

Article in Neurochemistry international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Hugo R AriasDepartment of Pharmacology and Physiology, College of Osteopathic Medicine, Oklahoma State University Center for Health Sciences, Tahlequah, OK, USA. Electronic address: hugo.arias@okstate.edu.
Xiao-Tao JinDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Sofía GallinoInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr. Héctor N. Torres, CONICET, Universidad de Buenos Aires, Argentina.
Can PengDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Dominik FeuerbachNovartis Institutes for Biomedical Research, Basel, Switzerland.
Jesús García-ColungaDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico.
Ana Belén ElgoyhenInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr. Héctor N. Torres, CONICET, Universidad de Buenos Aires, Argentina; Instituto de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Ryan M DrenanDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Marcelo O OrtellsFacultad de Medicina, Universidad de Morón, Morón and CONICET, Argentina. Electronic address: mortells@retina.ar.
Northwestern University · USUniversity of Buenos Aires · ARConsejo Nacional de Investigaciones Científicas y Técnicas · ARNovartis (Switzerland) · CHOklahoma State University Center for Health Sciences · USUniversidad Nacional Autónoma de México · MX

Funding

Identifying nicotine withdrawal mechanisms hidden within habenular complexityR01DA040626 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ryan Michael Drenan · 2016 to 2026
$4.0M
NIDA NIH HHS R01 DA040626
6 · The paper itself

Abstract

The inhibitory activity of (±)-citalopram on human (h) α3β4, α4β2, and α7 nicotinic acetylcholine receptors (AChRs) was determined by Ca

Indexed as

AnimalsAntidepressive AgentsAntidepressive Agents, TricyclicBinding, CompetitiveCalciumCitalopramHabenulaHEK293 CellsHumansImipramineModels, MolecularMolecular Docking SimulationMolecular Dynamics SimulationPatch-Clamp TechniquesReceptors, NicotinicXenopusalpha3beta4alpha5 receptor, humanAntidepressive AgentsAntidepressive Agents, TricyclicCalciumCitalopramImipramineReceptors, NicotinicBrain slices(±)-CitalopramMedial habenulaNicotinic acetylcholine receptorSelective serotonin reuptake inhibitor

Identifiers

PMID31545995
PMCPMC7221482
OpenAlexW2974463981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.