SynthesisNeuroscience and biobehavioral reviews2019
Impaired hippocampus-dependent associative learning as a mechanism underlying PTSD: A meta-analysis.
Synthesis in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Hippocampal CA2 modulates trace fear conditioning through circuit-specific control of CA1.bioRxiv : the preprint server for biology · 2026Article
- Targeting memory of embedded positive verbal content indirectly modulates negative visual memory.iScience · 2025Article
- Unraveling trauma memory: Differential functional connectivity profiles of anterior and posterior hippocampus in post-traumatic stress disorder and its dissociative subtype.Neuroimage. Reports · 2025Article
- Impaired mnemonic pattern separation associated with PTSD symptoms paradoxically improves with regular cannabis use.Npj mental health research · 2025Article
- Plasticity of human resilience mechanisms.Science advances · 2025Article
- Fear of Predators Suppresses Neurogenesis in the Brains of Wild Songbirds.Integrative organismal biology (Oxford, England) · 2025Article
- Translational approaches to the neurobiological study of conditional discrimination and inhibition: Implications for psychiatric disease.Behavioral neuroscience · 2024Review
- Integrating and fragmenting memories under stress and alcohol.Neurobiology of stress · 2024Article
- Cilostazol pretreatment prevents PTSD-related anxiety behavior through reduction of hippocampal neuroinflammation.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Context reexposure to bolster contextual dependency of emotional episodic memory.Scientific reports · 2023Article
- Functional connectivity of amygdala subnuclei in PTSD: a narrative review.Molecular psychiatry · 2023Review
- Trajectories of depression symptoms in a therapist-supported digital mental health intervention: a repeated measures latent profile analysis.Social psychiatry and psychiatric epidemiology · 2023Article
- Phosphodiesterase inhibitors in psychiatric disorders.Psychopharmacology · 2023Review
- Article
- Trauma and Remembering: From Neuronal Circuits to Molecules.Life (Basel, Switzerland) · 2022Review
- Spouse bereavement and brain pathologies: A propensity score matching study.Psychiatry and clinical neurosciences · 2022Article
- The pituitary adenylate cyclase-activating polypeptide system as a sex-specific modulator of hippocampal response to threat stimuli.Neurobiology of stress · 2022Article
- Scene Construction and Spatial Processing in Post-traumatic Stress Disorder.Frontiers in behavioral neuroscience · 2022Article
- Mapping structural covariance networks in children and adolescents with post-traumatic stress disorder after earthquake.Frontiers in psychiatry · 2022Article
- The Impact of Electroacupuncture Early Intervention on the Brain Lipidome in a Mouse Model of Post-traumatic Stress Disorder.Frontiers in molecular neuroscience · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Smaller hippocampal volume is associated with increased risk for PTSD following trauma, but the hippocampal functions involved remain unknown. We propose a conceptual model that identifies broad impairment in hippocampus-dependent associative learning as a vulnerability factor for PTSD. Associative learning of foreground cues and background context is required to form an integrated representation of an event. People with poor associative learning may have difficulty remembering who or what was present during a trauma, where the trauma occurred, or the sequence of events, which may contribute to PTSD symptoms. We argue that associative learning difficulties in PTSD exist for cues and context, regardless of the emotional nature of the information. This contrasts with PTSD models that focus exclusively on threat-processing or contextual-processing. In a meta-analysis, people with PTSD exhibited poor associative learning of multiple information types compared to those without PTSD. Differences were of medium effect size and similar magnitude for neutral and negative/trauma-related stimuli. We provide evidence for associative learning difficulties as a neurocognitive pathway that may contribute to PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.