Evidence map›Paper›PMID 31545922›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2019

Metformin alters the duodenal microbiome and decreases the incidence of pancreatic ductal adenocarcinoma promoted by diet-induced obesity.

Tien S Dong, Hui-Hua Chang, Meg Hauer, Venu Lagishetty, William Katzka, Enrique Rozengurt, Jonathan P Jacobs, Guido Eibl

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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  20. The Ocular Microbiome Is Altered by Sampling Modality and Age.Translational vision science & technology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tien S DongThe Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.ORCID 0000-0003-0105-8063
Hui-Hua ChangCURE: Digestive Diseases Research Center, David Geffen School of Medicine at the University of California, Los Angeles, California.
Meg HauerThe Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.
Venu LagishettyThe Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.
William KatzkaThe Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.
Enrique RozengurtThe Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.
Jonathan P JacobsThe Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.
Guido EiblCURE: Digestive Diseases Research Center, David Geffen School of Medicine at the University of California, Los Angeles, California.
University of California, Los Angeles · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
GASTROENTEROLOGYT32DK007180 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENSEN, DENNIS MICHAEL · 1986 to 2025
$10.0M
Targeting diet-induced promotion of Kras-initiated pancreatic adenocarcinomaP01CA163200 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PANDOL, STEPHEN J. · 2012 to 2016
$6.2M
PKD1 Signaling and Crosstalk Mechanisms in Intestinal Epithelial Cell RegulationR01DK100405 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 2014 to 2017
$1.3M
Identification of the growth-promoting PKD/YAP axis as a novel target for the statins in intestinal epithelial cells.I01BX003801 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI ROZENGURT, JUAN ENRIQUE · 2018 to 2021
–
BLRD VA I01 BX001473BLRD VA I01 BX003801CSRD VA IK2 CX001717NCI NIH HHS P01 CA163200NIDDK NIH HHS P30 DK041301NIDDK NIH HHS R01 DK100405NIDDK NIH HHS T32 DK007180
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC)'s growing incidence has been linked to the rise in obesity and type 2 diabetes mellitus. In previous work, we have shown that metformin can prevent the increased incidence of PDAC in a Kras

Indexed as

Carcinoma, Pancreatic DuctalDuodenumAnimalsDiabetes Mellitus, Type 2Diet, High-FatDisease Models, AnimalGastrointestinal MicrobiomeHypoglycemic AgentsMetforminMiceObesityTreatment OutcomeHypoglycemic AgentsMetforminclostridiummetforminmicrobiomeobesitypancreatic ductal adenocarcinomatype 2 diabetes mellitus

Identifiers

PMID31545922
PMCPMC6962494
OpenAlexW2975567055

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.