Evidence map›Paper›PMID 31545918›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2019

NSAID-induced injury of gastric epithelial cells is reversible: roles of mitochondria, AMP kinase, NGF, and PGE

Amrita Ahluwalia, Neil Hoa, Michael K Jones, Andrzej S Tarnawski

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Amrita AhluwaliaMedical and Research Services, Veterans Affairs Long Beach Healthcare System, Long Beach, California.ORCID 0000-0002-2064-5725
Neil HoaMedical and Research Services, Veterans Affairs Long Beach Healthcare System, Long Beach, California.
Michael K JonesMedical and Research Services, Veterans Affairs Long Beach Healthcare System, Long Beach, California.
Andrzej S TarnawskiMedical and Research Services, Veterans Affairs Long Beach Healthcare System, Long Beach, California.ORCID 0000-0002-6813-6698
University of California, Irvine · USVA Long Beach Healthcare System · US

Funding

BLRD VA I01 BX000626
6 · The paper itself

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (DFN) and indomethacin (INDO) are extensively used worldwide. Their main side effects are injury of the gastrointestinal tract, including erosions, ulcers, and bleeding. Since gastric epithelial cells (GEPCs) are crucial for mucosal defense and are the major target of injury, we examined the extent to which DFN- and INDO-induced GEPC injury can be reversed by nerve growth factor (NGF), 16,16 dimethyl prostaglandin E

Indexed as

Gastric MucosaMitochondria16,16-Dimethylprostaglandin E2Aminoimidazole CarboxamideAnimalsAnti-Inflammatory Agents, Non-SteroidalAnti-Ulcer AgentsCell DeathCells, CulturedCell SurvivalDiclofenacIndomethacinMembrane Potential, MitochondrialNerve Growth FactorRatsRibonucleosides16,16-Dimethylprostaglandin E2acadesineAminoimidazole CarboxamideAnti-Inflammatory Agents, Non-SteroidalAnti-Ulcer AgentsDiclofenacIndomethacinNerve Growth FactorRibonucleosides5-amino-imidazole-4-carboxamide ribonucleotideAMP-activated protein kinasediclofenacdm prostaglandin E2indomethacinmitochondrianerve growth factornon-steroidal anti-inflammatory drugs

Identifiers

PMID31545918
PMCPMC6962499
OpenAlexW2977119401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.