Evidence map›Paper›PMID 31545854›Full record

ArticleInternational journal of pharmaceutics: X2019

Real time calorimetric characterisation of clay - drug complex dispersions and particles.

A M Totea, I Dorin, G Gavrilov, P R Laity, B R Conway, L Waters, K Asare-Addo

Abstract read
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In one paragraph

Article in International journal of pharmaceutics: X, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A M ToteaSchool of Applied Sciences, Department of Pharmacy, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.
I DorinMalvern Panalytical Ltd., Malvern, UK.
G GavrilovWienerberger, Baneasa Business & Technology Park, Bucharest, Romania.
P R LaityDepartment of Materials Science and Engineering, University of Sheffield, Sir Robert Hadfield Building, Mappin Street, Sheffield S1 3JD, UK.
B R ConwaySchool of Applied Sciences, Department of Pharmacy, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.
L WatersSchool of Applied Sciences, Department of Pharmacy, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.
K Asare-AddoSchool of Applied Sciences, Department of Pharmacy, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isothermal titration calorimetry (ITC) along with attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM/EDX) and high-performance liquid chromatography (HPLC) were employed to investigate the process of adsorption of propranolol hydrochloride (PPN) onto magnesium aluminium silicate (MAS) and to characterise the MAS-PPN particles formed upon complexation. The composition of MAS was confirmed by infrared (IR) spectroscopy and a calcimeter. The calorimetric results confirmed the binding between PPN and MAS at various pHs and temperatures. The overall change in enthalpy was found to be exothermic with a comparatively small entropic contribution to the total change in Gibbs free energy. These findings suggest that the binding process was enthalpically driven and entropically unfavourable (lower affinity) suggesting hydrogen bonding and electrostatic interactions dominating the interaction. The variation of pH and temperature did not have a great impact on the thermodynamics of the binding process, as observed from the similarity in enthalpy (ΔH), entropy (ΔS) or Gibbs free energy (ΔG). A slight reduction in the binding affinity (K

Indexed as

ComplexationHCl, hydrochloric acidHPLC, high performance liquid chromatographyICH, International Conference on HarmonisationIsothermal titration calorimetryITC, isothermal titration calorimetryLOD, limit of detectionLOQ, limit of quantificationMagnesium aluminium silicateMAS, magnesium aluminium silicateMIM, multiple injection modePPN, propranolol hydrochloridePropranolol hydrochloriderpm, rotations per minuteRSD, relative standard deviationSIM, single injection mode

Identifiers

PMID31545854
PMCPMC6733304

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.