ArticlePLoS neglected tropical diseases2019
Rabies-induced behavioural changes are key to rabies persistence in dog populations: Investigation using a network-based model.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Time Series and Pattern of Dog Bites and Rabies in the Ashanti Region, Ghana, 2009-2019: A Call for Inter-Sectoral Collaboration in the Fight Against Rabies.Tropical medicine and infectious disease · 2026Article
- Epidemiological Analysis of Rabies Outbreaks in the European Union and Türkiye (2013-2023).Life (Basel, Switzerland) · 2026Article
- Development and application of web-based and mobile tools for risk-driven rabies control in Thailand.One health (Amsterdam, Netherlands) · 2025Article
- Tracking lethal threat: in-depth review of rabies.Open veterinary journal · 2023Review
- A worldwide perspective on large carnivore attacks on humans.PLoS biology · 2023Article
- Rabies in the Tropics.Current tropical medicine reports · 2022Review
- Analyses of Contact Networks of Community Dogs on a University Campus in Nakhon Pathom, Thailand.Veterinary sciences · 2021Article
- Predictors of free-roaming domestic dogs' contact network centrality and their relevance for rabies control.Scientific reports · 2021Article
- Mathematical modelling and phylodynamics for the study of dog rabies dynamics and control: A scoping review.PLoS neglected tropical diseases · 2021Article
- Rabies in Our Neighbourhood: Preparedness for an Emerging Infectious Disease.Pathogens (Basel, Switzerland) · 2021Review
- Risk factors for rabid animal bites: a study in domestic ruminants in Mymensingh district, Bangladesh.Epidemiology and infection · 2021Article
- Behavioral manipulation-key to the successful global spread of the new coronavirus SARS-CoV-2?Journal of medical virology · 2021Article
- Modelling the factors affecting the probability for local rabies elimination by strategic control.PLoS neglected tropical diseases · 2021Article
- Could a rabies incursion spread in the northern Australian dingo population? Development of a spatial stochastic simulation model.PLoS neglected tropical diseases · 2021Article
- Modeling the Effect of Bovine Viral Diarrhea Virus in Australian Beef Herds.Frontiers in veterinary science · 2021Article
- Update on lyssaviruses and rabies: will past progress play as prologue in the near term towards future elimination?Faculty reviews · 2020Review
- A Practical Introduction to Mechanistic Modeling of Disease Transmission in Veterinary Science.Frontiers in veterinary science · 2020Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine rabies was endemic pre-urbanisation, yet little is known about how it persists in small populations of dogs typically seen in rural and remote regions. By simulating rabies outbreaks in such populations (50-90 dogs) using a network-based model, our objective was to determine if rabies-induced behavioural changes influence disease persistence. Behavioural changes-increased bite frequency and increased number or duration of contacts (disease-induced roaming or paralysis, respectively)-were found to be essential for disease propagation. Spread occurred in approximately 50% of model simulations and in these, very low case rates (2.0-2.6 cases/month) over long durations (95% range 20-473 days) were observed. Consequently, disease detection is a challenge, risking human infection and spread to other communities via dog movements. Even with 70% pre-emptive vaccination, spread occurred in >30% of model simulations (in these, median case rate was 1.5/month with 95% range of 15-275 days duration). We conclude that the social disruption caused by rabies-induced behavioural change is the key to explaining how rabies persists in small populations of dogs. Results suggest that vaccination of substantially greater than the recommended 70% of dog populations is required to prevent rabies emergence in currently free rural areas.
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