ArticleAmerican journal of respiratory and critical care medicine2020
Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension.
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Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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79citing papers in PubMed
8.9field-weighted citation impact, top 2% of its field
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Who cites it
79 citing papers in PubMed, 120 citations in OpenAlex.
- Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex-Differential Proteins and Candidate Therapeutic Targets.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Role of CD4+ T cell mannose binding lectin in Schistosoma-induced pulmonary hypertension.JCI insight · 2026Article
- Fisetin alleviates pulmonary arterial hypertension by inhibiting the TGF-β1/Smad 2/3 signaling pathway.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026Article
- Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions.Comprehensive Physiology · 2026Review
- Advances in the pathogenesis and clinical management of pulmonary hypertension.Medical review (2021) · 2026Review
- Beyond the Vasculature: The Emerging Role of Systemic Metabolism and Immunometabolism in Pulmonary Arterial Hypertension.International journal of molecular sciences · 2026Review
- Article
- Mixed effects of complement in a chronic murine model of inflammatory erosive arthritis and pulmonary vascular disease.PloS one · 2026Article
- Rest-Activity Timing Phenotypes and Mental Health: A Longitudinal Analysis of 24-Hour Accelerometry in Population-Based Cohorts.Health data science · 2026Article
- Complement C3 in panvascular disease: a central integrator of immune signaling and vascular remodeling.Clinical science (London, England : 1979) · 2025Review
- Role of lipid droplets in pulmonary arterial hypertension: focusing on pulmonary artery smooth muscle cell proliferation.Lipids in health and disease · 2025Review
- A Lifelong Journey in the Field of the Pulmonary Circulation: Perspectives Through the Lens of the Cardiovascular Pulmonary Research Laboratory.Pulmonary circulation · 2025Article
- Enigmatic Roles of Complement Anaphylatoxin Signaling in Health and Disease.Immune network · 2025Review
- TNF drives aberrant BMP signaling to induce endothelial and mesenchymal dysregulation in pulmonary hypertension.JCI insight · 2025Article
- Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- When cell teamwork turns toxic.eLife · 2025Article
- Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease.eLife · 2025Article
- Using network analysis to identify central symptoms of depression and anxiety in different profiles of infertility patients.BMC psychiatry · 2025Article
- An intracellular complement system drives metabolic and proinflammatory reprogramming of vascular fibroblasts in pulmonary hypertension.JCI insight · 2025Article
- Establishment of an in vivo analytical method for detecting total anti-UFH activity and pharmacokinetic study in PS and R15 in rats.PloS one · 2025Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 4 institutions in 2 countries.
Maria G FridDivision of Critical Care Medicine and Cardiovascular Pulmonary Research, Departments of Pediatrics and Medicine.
B Alexandre McKeonDivision of Critical Care Medicine and Cardiovascular Pulmonary Research, Departments of Pediatrics and Medicine.
Joshua M ThurmanDivision of Renal Medicine, Department of Medicine.
Bradley A MaronDivision of Cardiovascular Medicine, Department of Medicine, School of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Min LiDivision of Critical Care Medicine and Cardiovascular Pulmonary Research, Departments of Pediatrics and Medicine.
Hui ZhangDivision of Critical Care Medicine and Cardiovascular Pulmonary Research, Departments of Pediatrics and Medicine.
Sushil KumarDivision of Critical Care Medicine and Cardiovascular Pulmonary Research, Departments of Pediatrics and Medicine.
Timothy SullivanDivision of Critical Care Medicine and Cardiovascular Pulmonary Research, Departments of Pediatrics and Medicine.
Jennifer LaskowskyDivision of Renal Medicine, Department of Medicine.
Mehdi A FiniDivision of Critical Care Medicine and Cardiovascular Pulmonary Research, Departments of Pediatrics and Medicine.
Samantha HuDivision of Critical Care Medicine and Cardiovascular Pulmonary Research, Departments of Pediatrics and Medicine.
Rubin M TuderDivision of Pulmonary and Critical Care Medicine, Department of Medicine, and.
Aneta GandjevaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, and.
Martin R WilkinsDepartment of Medicine and National Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Christopher J RhodesDepartment of Medicine and National Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Pavandeep GhataorheDepartment of Medicine and National Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Jane A LeopoldDivision of Cardiovascular Medicine, Department of Medicine, School of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Rui-Sheng WangChanning Division of Network Medicine, Department of Medicine, School of Medicine, Brigham Health Brigham and Women's Hospital, Boston, Massachusetts.
V Michael HolersDivision of Rheumatology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Kurt R StenmarkDivision of Critical Care Medicine and Cardiovascular Pulmonary Research, Departments of Pediatrics and Medicine.ORCID 0000-0001-6918-6411
Pulmonary and Critical Care Associates · USBrigham and Women's Hospital · USImperial College London · GBUniversity of Colorado Anschutz Medical Campus · US
Funding
VRAC and Rho in pulmonary EC proliferationP01HL014985 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI STENMARK, KURT R. · 1985 to 2019
$35.1MRole of Complement-Driven Pulmonary Vascular Inflammation in PHP01HL152961 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DELANEY, CASSIDY A · 2020 to 2024
$14.1MPulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1MTranslational Pulmonary Vascular Biology ProgramT32HL007171 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Sonia Castro Flores, Tim Lahm · 1985 to 2026
$9.4MThe Complement System and Ischemic Acute Renal FailureR01DK076690 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Joshua M Thurman · 2008 to 2026
$6.6MTargeting FAK-NEDD9 protein-protein interaction to prevent focal adhesion assembly and vascular proliferation in pulmonary arterial hypertensionR01HL139613 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Sirano Dhe-Paganon, Bradley Maron · 2018 to 2026
$4.1MIntergrated Endothelial Phenotyping to Redefine Pulmonary HypertensionU01HL125215 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEOPOLD, JANE A, WAXMAN, AARON B · 2014 to 2018
$1.7MImmunologic Mechanisms of Progressive GlomerulosclerosisR01DK113586 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI THURMAN, JOSHUA M · 2017 to 2020
$1.4MFibrosome regulation by aldosterone in pulmonary vascular diseaseR56HL131787 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARON, BRADLEY · 2017 to 2017
$445kNetwork medicine, risk stratification, and pulmonary hypertensionR21HL145420 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARON, BRADLEY · 2019 to 2020
$287kBritish Heart Foundation FS/15/59/31839NHLBI NIH HHS P01 HL014985NHLBI NIH HHS P01 HL152961NHLBI NIH HHS R01 HL139613NHLBI NIH HHS R21 HL145420NHLBI NIH HHS R24 HL123767NHLBI NIH HHS R56 HL131787NHLBI NIH HHS T32 HL007171NHLBI NIH HHS U01 HL125215NIDDK NIH HHS R01 DK076690NIDDK NIH HHS R01 DK113586
Abstract
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Indexed as
AnimalsComplement ActivationComplement C3Complement C5Complement Factor BComplement Pathway, AlternativeDisease Models, AnimalFibroblastsGranulocyte-Macrophage Colony-Stimulating FactorHumansHypertension, PulmonaryHypoxiaImmunoglobulin GImmunoglobulinsInflammationMiceComplement C3Complement C5Complement Factor BGranulocyte-Macrophage Colony-Stimulating FactorImmunoglobulin GImmunoglobulinsbiomarkersGM-CSFhypoxiainflammationvascular remodeling
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.