Evidence map›Paper›PMID 31545596›Full record

ArticleACS chemical neuroscience2019

Hexahydropyrrolo[2,3-

Deborah Doens, Mario E Valdés-Tresanco, Velmarini Vasquez, Maria Beatriz Carreira, Yila De La Guardia, David E Stephens, Viet D Nguyen, Vu T Nguyen, Jianhua Gu, Muralidhar L Hegde and 4 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Isolation, modification, structure-activity relationship (SAR) and molecular docking studies of isoflavones from Derris scandens as potent dual AChE/BuChE inhibitors.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Deborah DoensCentro de Biología Celular y Molecular de Enfermedades , Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP) , City of Knowledge Edif #208 , Panama 0843-01103 , Panama.
Mario E Valdés-TresancoCentro de Estudios de Proteínas, Facultad de Biología , Universidad de La Habana , Calle 25 No. 455 , Vedado, La Habana , Cuba.
Velmarini VasquezDepartment of Biotechnology , Acharya Nagarjuna University , Nagarjuna Nagar , Guntur , Andhra Pradesh 522510 , India.
Maria Beatriz CarreiraCentro de Neurociencias , INDICASAT-AIP , City of Knowledge Edif #208 , Panama , 0843-01103 , Panama.
Yila De La GuardiaCentro de Biología Celular y Molecular de Enfermedades , Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP) , City of Knowledge Edif #208 , Panama 0843-01103 , Panama.
David E StephensDepartment of Chemistry , University of Texas at San Antonio , One UTSA Circle , San Antonio , Texas 78249 , United States.
Viet D NguyenDepartment of Chemistry , University of Texas at San Antonio , One UTSA Circle , San Antonio , Texas 78249 , United States.
Vu T NguyenDepartment of Chemistry , University of Texas at San Antonio , One UTSA Circle , San Antonio , Texas 78249 , United States.ORCID 0000-0001-8804-0282
Jianhua GuAFM SEM Core , Houston Methodist Research Institute , Houston , Texas 77030 , United States.
Muralidhar L HegdeDepartment of Radiation Oncology , Houston Methodist Research Institute , Houston , Texas 77030 , United States.ORCID 0000-0001-7333-8123
Oleg V LarionovDepartment of Chemistry , University of Texas at San Antonio , One UTSA Circle , San Antonio , Texas 78249 , United States.ORCID 0000-0002-3026-1135
Pedro A ValienteCentro de Estudios de Proteínas, Facultad de Biología , Universidad de La Habana , Calle 25 No. 455 , Vedado, La Habana , Cuba.ORCID 0000-0002-4776-6017
Ricardo LleonartCentro de Biología Celular y Molecular de Enfermedades , Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP) , City of Knowledge Edif #208 , Panama 0843-01103 , Panama.
Patricia L FernándezCentro de Biología Celular y Molecular de Enfermedades , Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP) , City of Knowledge Edif #208 , Panama 0843-01103 , Panama.ORCID 0000-0002-0762-0566
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología · PAThe University of Texas at San Antonio · USHouston Methodist · USUniversity of Havana · CUAcharya Nagarjuna University · IN

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Etiological Linkage of DNA Damage/Repair Deficiency in Neurodegenerative DiseasesR01NS088645 · NINDS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI HEGDE, MURALIDHAR L · 2015 to 2019
$1.8M
The mode-of-action for pheromone-induced paralysis in Pristionchus pacificusSC3GM105579 · NIGMS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI HONG, RAY L · 2013 to 2020
$870k
New catalytic methods for the synthesis of oxazine natural productsSC3GM109853 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI LARIONOV, OLEG V · 2014 to 2017
$441k
NIGMS NIH HHS SC3 GM105579NIGMS NIH HHS SC3 GM109853NIH HHS P40 OD010440NINDS NIH HHS R01 NS088645
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common form of dementia among the elderly and has become a leading public health concern worldwide. It represents a huge economic and psychological burden to caregivers and families. The presence of extracellular amyloid beta (Aβ) plaques is one of the hallmarks of this neurodegenerative disorder. Amyloid plaques are comprised of aggregates of Aβ peptides, mainly Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsIndolesPC12 CellsPeptide FragmentsProtein AggregatesProtein Aggregation, PathologicalPyrrolesRatsAmyloid beta-Peptideshexahydropyrrolo(2,3-b)indoleIndolesPeptide FragmentsProtein AggregatesPyrrolesaggregationAlzheimer’s diseaseamyloid betaHPI compounds

Identifiers

PMID31545596
PMCPMC8130500
OpenAlexW2976839860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.