ArticleMolecular medicine reports2019
Role of CCR7 on dendritic cell‑mediated immune tolerance in the airways of allergy‑induced asthmatic rats.
Article in Molecular medicine reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- In-silico identification and prioritization of therapeutic targets of asthma.Scientific reports · 2023Article
- Identification of biomarkers and pathogenesis in severe asthma by coexpression network analysis.BMC medical genomics · 2021Article
- Intranasal administration of regulatory dendritic cells is useful for the induction of nasal mucosal tolerance in a mice model of allergic rhinitis.The World Allergy Organization journal · 2020Article
- Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa.Clinical and translational allergy · 2020Review
- Comparison of the Gut Microbiota Disturbance in Rat Models of Irritable Bowel Syndrome Induced by Maternal Separation and Multiple Early-Life Adversity.Frontiers in cellular and infection microbiology · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DCs) have an important role in initiating and maintaining the immune inflammatory response in allergic asthma, and CC chemokine receptor 7 (CCR7) is directly involved in the pathogenesis of DC‑ and T cell‑mediated allergic asthma. The present study aimed to investigate the effects of CCR7 on DC‑mediated immune tolerance in allergic asthma. In the present study, bone marrow‑derived DCs were transfected with an adenovirus encoding the rat CCR7 gene or a short hairpin RNA targeting CCR7 (sh‑CCR7). Rats injected with DCs overexpressing CCR7 or presenting CCR7 knockdown were examined. After the rats were injected with DCs via the tail vein, bronchoalveolar lavage fluid was collected to assess its cellular composition. The protein expression levels of CCR7 in DCs were determined using immunohistochemistry and western blot analysis. The protein expression levels of interferon‑γ (IFN‑γ), interleukin‑4 (IL‑4), IL‑10, IL‑12, transforming growth factor‑β (TGF‑β) and immunoglobulin E (IgE) were determined by ELISA. Compared with the control group, the protein expression level of CCR7 was significantly higher in the CCR7 overexpression group and significantly lower in sh‑CCR7 group. Similarly, the number of DCs was higher in the CCR7 overexpression group and lower in the sh‑CCR7 group. The protein expression levels of IL‑10 and TGF‑β were significantly lower in the CCR7 overexpression group and higher in the sh‑CCR7 group. In addition, the expression levels of IL‑4, IL‑12, IFN‑γ and IgE were higher in the CCR7 overexpression group and lower in the sh‑CCR7 group. The present results suggested that the role of cytokines and IgE in immune inflammation and immune tolerance in allergic asthma may be associated with the expression level of CCR7 in DCs, suggesting that CCR7 may serve a role in DC‑mediated immune tolerance in allergic asthma.
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