Evidence map›Paper›PMID 31545351›Full record

ArticleAmerican journal of hypertension2019

Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group.

Marguerite R Irvin, Colleen M Sitlani, James S Floyd, Bruce M Psaty, Joshua C Bis, Kerri L Wiggins, Eric A Whitsel, Til Sturmer, James Stewart, Laura Raffield and 34 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Genes, environment, and African ancestry in cardiometabolic disorders.Trends in endocrinology and metabolism: TEM · 2023
    Review
  9. Biomedicines · 2023
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 19 institutions in 5 countries.

Marguerite R IrvinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
James S FloydCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Eric A WhitselDepartment of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Til SturmerDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
James StewartDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Laura RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Fangui SunDepartment of Biostatistics, Boston University, Boston, Maryland, USA.
Ching-Ti LiuDepartment of Biostatistics, Boston University, Boston, Maryland, USA.
Hanfei XuDepartment of Biostatistics, Boston University, Boston, Maryland, USA.
Adrienne L CupplesDepartment of Biostatistics, Boston University, Boston, Maryland, USA.
Rikki M TannerDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Peter RossingSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Albert SmithIcelandic Heart Association, Kopavogur, Iceland.
Nuno R ZilhãoIcelandic Heart Association, Kopavogur, Iceland.
Lenore J LaunerLaboratory of Epidemiology and Population Science, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA.
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Jie YaoInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Xiaohui LiInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Nita LimdiDepartment of Neurology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Aishwarya SundaresanDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Leslie LangeDepartment of Medicine, University of Colorado-Denver, Aurora, Colorado, USA.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
David J StottInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Ian FordRobertson Center for Biostatistics, University of Glasgow, Glasgow, UK.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Vilmundur GudnasonDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Dennis O Mook-KanamoriDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Stella TrompetDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Walter PalmasDepartment of Medicine, Columbia University Medical Center, New York, New York, USA.
Helen R WarrenWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Jacklyn N HellwegeBiomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, Tennessee, USA.
Ayush GiriBiomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, Tennessee, USA.
Christopher O'donnellVA Boston Health Care System, Boston, Massachusetts, USA.
Adriana M HungBiomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, Tennessee, USA.
Todd L EdwardsBiomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, Tennessee, USA.
Tarunveer S AhluwaliaDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Donna K ArnettDeans Office, School of Public Health, University of Kentucky, Lexington, Kentucky, USA.
Christy L AveryDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Leiden University Medical Center · NLUniversity of North Carolina at Chapel Hill · USBoston University · USThe Lundquist Institute · USUniversity of Alabama at Birmingham · USUniversity of Washington · USVanderbilt University · USSteno Diabetes Centers · DKUniversity of Glasgow · GBBrigham and Women's Hospital · USColumbia University Irving Medical Center · USIcelandic Heart Association · ISKaiser Permanente Washington Health Research Institute · USNational Institute on Aging · USQueen Mary University of London · GBUniversity of Colorado Denver · USUniversity of Iceland · ISUniversity of Kentucky · USUniversity of Mississippi Medical Center · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
The Family Blood Pressure Program (HyperGEN Network)U01HL054471 · NHLBI · UNIVERSITY OF UTAH · PI HUNT, STEVEN C. · 2000 to 2007
$7.4M
Genome-wide case-only study of antihypertensive drug-gene interactionsR01HL085251 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2007 to 2010
$7.2M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
NCATS NIH HHS UL1 TR000124NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS K08 HL116640NHLBI NIH HHS K24 HL133373NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL073410NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL054471NHLBI NIH HHS U01 HL054472NHLBI NIH HHS U01 HL054473NHLBI NIH HHS U01 HL054495NHLBI NIH HHS U01 HL054496NHLBI NIH HHS U01 HL054509NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629NICHD NIH HHS K12 HD043483NIDA NIH HHS HHSN271201200022CNIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK079626NIH HHS S10 OD023680NIMHD NIH HHS HHSN268201800013I
6 · The paper itself

Abstract

backgroundOnly a handful of genetic discovery efforts in apparent treatment-resistant hypertension (aTRH) have been described.

methodsWe conducted a case-control genome-wide association study of aTRH among persons treated for hypertension, using data from 10 cohorts of European ancestry (EA) and 5 cohorts of African ancestry (AA). Cases were treated with 3 different antihypertensive medication classes and had blood pressure (BP) above goal (systolic BP ≥ 140 mm Hg and/or diastolic BP ≥ 90 mm Hg) or 4 or more medication classes regardless of BP control (nEA = 931, nAA = 228). Both a normotensive control group and a treatment-responsive control group were considered in separate analyses. Normotensive controls were untreated (nEA = 14,210, nAA = 2,480) and had systolic BP/diastolic BP < 140/90 mm Hg. Treatment-responsive controls (nEA = 5,266, nAA = 1,817) had BP at goal (<140/90 mm Hg), while treated with one antihypertensive medication class. Individual cohorts used logistic regression with adjustment for age, sex, study site, and principal components for ancestry to examine the association of single-nucleotide polymorphisms with case-control status. Inverse variance-weighted fixed-effects meta-analyses were carried out using METAL.

resultsThe known hypertension locus, CASZ1, was a top finding among EAs (P = 1.1 × 10-8) and in the race-combined analysis (P = 1.5 × 10-9) using the normotensive control group (rs12046278, odds ratio = 0.71 (95% confidence interval: 0.6-0.8)). Single-nucleotide polymorphisms in this locus were robustly replicated in the Million Veterans Program (MVP) study in consideration of a treatment-responsive control group. There were no statistically significant findings for the discovery analyses including treatment-responsive controls.

conclusionThis genomic discovery effort for aTRH identified CASZ1 as an aTRH risk locus.

Indexed as

Pharmacogenomic VariantsPolymorphism, Single NucleotideAgedAntihypertensive AgentsBlack or African AmericanBlood PressureCase-Control StudiesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADrug ResistanceDystrophin-Associated ProteinsEuropeFemaleGenetic LociGenome-Wide Association StudyAntihypertensive AgentsCASZ1 protein, humanDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanDTNB protein, humanDystrophin-Associated ProteinsMYO5B protein, humanMyosin Heavy ChainsMyosin Type VNeuropeptidesTranscription Factorsblood pressuregenome-wide association studyhypertensionsevere hypertensiontreatment-resistant hypertension

Identifiers

PMID31545351
PMCPMC6856621
OpenAlexW2975626177

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.