Evidence map›Paper›PMID 31545149›Full record

ArticleCirculation research2019

Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body.

Mi-Kyung Shin, Candela Caballero Eraso, Yun-Ping Mu, Chenjuan Gu, Bonnie H Y Yeung, Lenise J Kim, Xiao-Ru Liu, Zhi-Juan Wu, Omkar Paudel, Luis E Pichard and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 78 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Transient Receptor Potential Vanilloid 4 (TRPV4) in the Human Carotid Body.International journal of molecular sciences · 2025
    Article
  6. Article
  7. Article
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  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Carotid body denervation improves hyperglycemia in obese mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
  17. Role of TRP Channels in Metabolism-Related Diseases.International journal of molecular sciences · 2024
    Review
  18. Review
  19. Article
  20. Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons.Autonomic neuroscience : basic & clinical · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Mi-Kyung ShinFrom the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (M.-K.S., C.G., B.H.Y.Y., L.J.K., J.S.K.S., V.Y.P.).
Candela Caballero ErasoUnidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Hospital Universitario Virgen del Rocío/Universidad de Sevilla, Spain (C.C.E.).
Yun-Ping MuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China (Y.-P.M., X.-R.L., Z.-J.W.).
Chenjuan GuFrom the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (M.-K.S., C.G., B.H.Y.Y., L.J.K., J.S.K.S., V.Y.P.).
Bonnie H Y YeungFrom the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (M.-K.S., C.G., B.H.Y.Y., L.J.K., J.S.K.S., V.Y.P.).
Lenise J KimFrom the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (M.-K.S., C.G., B.H.Y.Y., L.J.K., J.S.K.S., V.Y.P.).
Xiao-Ru LiuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China (Y.-P.M., X.-R.L., Z.-J.W.).
Zhi-Juan WuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China (Y.-P.M., X.-R.L., Z.-J.W.).
Omkar PaudelDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (O.P., L.E.P., M.S.).
Luis E PichardDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (O.P., L.E.P., M.S.).
Machiko ShirahataDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (O.P., L.E.P., M.S.).
Wan-Yee Tang
James S K ShamFrom the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (M.-K.S., C.G., B.H.Y.Y., L.J.K., J.S.K.S., V.Y.P.).
Vsevolod Y PolotskyFrom the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (M.-K.S., C.G., B.H.Y.Y., L.J.K., J.S.K.S., V.Y.P.).
Johns Hopkins University · USFujian Medical University · CNHospital Universitario Virgen del Rocío · ES

Funding

Melanocortin 4 signaling in the carotid body in obesityR01HL133100 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Vsevolod Y Polotsky, Wan-yee Tang · 2016 to 2026
$7.1M
Treatment of Sleep Apnea by Targeting Leptin SignalingR01HL128970 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MENDELOWITZ, DAVID, POLOTSKY, VSEVOLOD Y · 2015 to 2023
$5.4M
The role of obesity in biological responses to particulate matter in miceP50ES018176 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2015 to 2019
$4.8M
Chemogenetic approach to treat Obstructive Sleep ApneaR01HL138932 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POLOTSKY, VSEVOLOD Y · 2017 to 2020
$2.4M
EPA R836152C003NHLBI NIH HHS R01 HL128970NHLBI NIH HHS R01 HL133100NHLBI NIH HHS R01 HL138932NIEHS NIH HHS P50 ES018176
6 · The paper itself

Abstract

rationaleObesity leads to resistant hypertension and mechanisms are poorly understood, but high plasma levels of leptin have been implicated. Leptin increases blood pressure acting both centrally in the dorsomedial hypothalamus and peripherally. Sites of the peripheral hypertensive effect of leptin have not been identified. We previously reported that leptin enhanced activity of the carotid sinus nerve, which transmits chemosensory input from the carotid bodies (CBs) to the medullary centers, and this effect was abolished by nonselective blockers of Trp (transient receptor potential) channels. We searched our mouse CB transcriptome database and found that the Trpm7 (transient receptor potential melastatin 7) channel was the most abundant Trp channel.

objectiveTo examine if leptin induces hypertension acting on the CB Trpm7. METHODS AND

resultsC57BL/6J (n=79), leptin receptor (

conclusionsWe conclude that leptin induces hypertension acting on Trmp7 in CB, which opens horizons for new therapy.

Indexed as

Blood PressureLeptinAnimalsAntihypertensive AgentsCarotid BodyDenervationDisease Models, AnimalHypertensionMaleMice, Inbred C57BLMice, KnockoutObesityReceptors, LeptinSignal TransductionTRPM Cation ChannelsAntihypertensive AgentsLeptinleptin receptor, mouseReceptors, LeptinTrpm7 protein, mouseTRPM Cation Channelscarotid bodyhypertensionleptinobesitytransient receptor potential channels

Identifiers

PMID31545149
PMCPMC6842127
OpenAlexW2974397777

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.