ArticleThe Journal of clinical endocrinology and metabolism2020
Body Composition and Markers of Cardiometabolic Health in Transgender Youth Compared With Cisgender Youth.
Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02550431 (Trans Health), which is not on this map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trans Health: Evaluation of Markers of Cardio-metabolic Health and Well-being in Transgender Youth
Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- Cardiometabolic diseases in transgender populations.Cardiovascular diabetology. Endocrinology reports · 2026Review
- Therapeutic Issues Associated with Gender-Affirming Hormone Therapy in Transgender Individuals: A Systematic Review Relevant to Community Pharmacy Practice.Pharmacy (Basel, Switzerland) · 2026Review
- Cardiometabolic benefits and risks for transgender youth with the initiation of gender-affirming hormone therapy: a case series.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Factors Associated with Medical Mistrust Among Sexual and Gender Minority Young Adults.Sexuality research & social policy : journal of NSRC : SR & SP · 2026Article
- Observational
- Psychological and Physical Health Outcomes Associated with Gender-Affirming Medical Care for Transgender and Gender-Diverse Youth: A Critical Review.Healthcare (Basel, Switzerland) · 2025Review
- Cross-Sex Hormone Therapy Is Associated With Loss of Circadian Rhythm in the Male Rat.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Gender-affirming hormone therapy: effects on cardiovascular risk and vascular function.Endocrine connections · 2025Article
- Effects of puberty suppression on bone, body composition, handgrip strength and glucolipid profile in early-pubertal transgender adolescents.International journal of transgender health · 2025Article
- Charting a Path Toward Improving Detection and Clinical Outcomes for Eating Disorders in Cismales and Gender-Diverse Patients.Focus (American Psychiatric Publishing) · 2024Review
- Insulin sensitivity, body composition and bone mineral density after testosterone treatment in transgender youth with and without prior GnRH agonist therapy.Journal of clinical & translational endocrinology · 2024Article
- Adolescent gender dysphoria management: position paper from the Italian Academy of Pediatrics, the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, the Italian Society of Adolescent Medicine and the Italian Society of Child and Adolescent Neuropsychiatry.Italian journal of pediatrics · 2024Article
- Bone Density in Transgender Youth on Gender-Affirming Hormone Therapy.Journal of the Endocrine Society · 2024Article
- Cardiovascular Risk in Transgender People With Gender-Affirming Hormone Treatment.Circulation reports · 2023Review
- Physical Inactivity and the Role of Bullying Among Gender Minority Youth Participating in the 2017 and 2019 Youth Risk Behavior Survey.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2023Article
- Gender-Affirming Care of Transgender and Gender-Diverse Youth: Current Concepts.Annual review of medicine · 2023Review
- Multicenter Analysis of Cardiometabolic-related Diagnoses in Transgender and Gender-Diverse Youth: A PEDSnet Study.The Journal of clinical endocrinology and metabolism · 2022Article
- The effect of gender-affirming hormone treatment on serum creatinine in transgender and gender-diverse youth: implications for estimating GFR.Pediatric nephrology (Berlin, Germany) · 2022Observational
- Care for Transgender Young People.Hormone research in paediatrics · 2022Review
- Subcutaneous Testosterone Is Effective and Safe as Gender-Affirming Hormone Therapy in Transmasculine and Gender-Diverse Adolescents and Young Adults: A Single Center's 8-Year Experience.Transgender health · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
contextAs many as 1.8% of adolescents identify as transgender and many more seek care, yet the impact of gender-affirming hormone therapy (GAHT) on cardiometabolic health is unknown.
objectiveTo determine insulin sensitivity and body composition among transgender females (TF) and males (TM) on estradiol or testosterone, compared with cisgender females (CF) and males (CM).
designPilot, cross-sectional study conducted from 2016-2018.
settingAcademic regional transgender referral center.
participantsTransgender adolescents on either testosterone or estradiol for at least 3 months were recruited. Nineteen TM were matched to 19 CM and 42 CF on pubertal stage and body mass index (BMI). Eleven TF were matched to 23 CF and 13 TF to 24 CM on age and BMI.
main outcome measures1/[fasting insulin] and body composition (dual-energy x-ray absorptiometry).
resultsTotal body fat was lower in TM than CF mean ± SD: (29% ± 7% vs 33% ± 7%; P = 0.002) and higher than in CM (28% ± 7% vs 24% ± 9%; P = 0.047). TM had higher lean mass than CF (68% ± 7% vs 64% ± 7%, P = 0.002) and lower than CM (69% ± 7% vs 73% ± 8%; P = 0.029). Insulin sensitivity was not different between the groups.TF had lower body fat than CF (31% ± 7% vs 35% ± 8%; P = 0.033) and higher than CM (28% ± 6% vs 20% ± 10%; P = 0.001). TF had higher lean mass than CF (66% ± 6% vs 62% ± 7%; P = 0.032) and lower than CM (69% ± 5% vs 77% ± 9%; P = 0.001). TF were more insulin resistant than CM (0.078 ± 0.025 vs 0.142 ± 0.064 mL/μU; P = 0.011).
conclusionsTransgender adolescents on GAHT have significant differences in body composition compared with cisgender controls, with a body composition intermediate between BMI-matched CMs and CFs. These changes in body composition may have consequences for the cardiometabolic health of transgender adolescents. CLINICALTRIALS.GOV: NCT02550431.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.