Evidence map›Paper›PMID 31544820›Full record

ArticleAntibodies (Basel, Switzerland)2019

Cross-Reactive and Lineage-Specific Single Domain Antibodies against Influenza B Hemagglutinin.

Walter Ramage, Tiziano Gaiotto, Christina Ball, Paul Risley, George W Carnell, Nigel Temperton, Chung Y Cheung, Othmar G Engelhardt, Simon E Hufton

Open access · goldAbstract read
In one paragraph

Article in Antibodies (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

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  16. Special Issue: Nanobody.Antibodies (Basel, Switzerland) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Walter RamageBiotherapeutics Division, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK. walter.ramage@nibsc.org.
Tiziano GaiottoBiotherapeutics Division, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK. Tiziano.Gaiotto@gmail.com.
Christina BallBiotherapeutics Division, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK. chris.ball@nibsc.org.
Paul RisleyBiotherapeutics Division, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK. paul.risley@nibsc.org.
George W CarnellInfectious Diseases and Allergy Group, School of Pharmacy, University of Kent, Kent ME4 4TB, UK. g.carnell@gmail.com.ORCID 0000-0001-8875-0989
Nigel TempertonInfectious Diseases and Allergy Group, School of Pharmacy, University of Kent, Kent ME4 4TB, UK. n.temperton@kent.ac.uk.ORCID 0000-0002-7978-3815
Chung Y CheungDivision of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK. chung.cheung@hli.ubc.ca.
Othmar G EngelhardtDivision of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK. othmar.engelhardt@nibsc.org.
Simon E HuftonBiotherapeutics Division, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK. simon.hufton@nibsc.org.
National Institute for Biological Standards and Control · GBUniversity of Kent · GB

Funding

Biomedical Advanced Research and Development Authority Contract No. HHSO100201300005C
6 · The paper itself

Abstract

Influenza B virus (IBV) circulates in the human population and causes considerable disease burden worldwide, each year. Current IBV vaccines can struggle to mount an effective cross-reactive immune response, as strains become mismatched, due to constant antigenic changes. Additional strategies which use monoclonal antibodies, with broad reactivity, are of considerable interest, both, as diagnostics and as immunotherapeutics. Alternatives to conventional monoclonal antibodies, such as single domain antibodies (Nanobodies

Indexed as

epitope mappinghemagglutinininfluenzainfluenza B virusNanobodyTMphage displaysingle domain antibodyyeast display

Identifiers

PMID31544820
PMCPMC6640691
OpenAlexW2913263369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.