ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
Early-life injury produces lifelong neural hyperexcitability, cognitive deficit and altered defensive behaviour in the squid
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Identification of molecular nociceptors in Octopus vulgaris through functional characterisation in Caenorhabditis elegans.Biology open · 2026Article
- Article
- Octopus track chemosensory plumes to find food.PloS one · 2025Article
- Post-injury pain and behaviour: a control theory perspective.Nature reviews. Neuroscience · 2023Review
- Evaluation of Candidates for Systemic Analgesia and General Anesthesia in the Emerging Model Cephalopod,Biology · 2023Article
- Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization ineLife · 2023Article
- Pain: Behavioural expression and response in an evolutionary framework.Evolution, medicine, and public health · 2023Article
- Article
- Animal sentience.Philosophy compass · 2022Article
- A pilot investigation of the efficacy and safety of magnesium chloride and ethanol as anesthetics inFrontiers in physiology · 2022Article
- Painful Truth: The Need to Re-Center Chronic Pain on the Functional Role of Pain.Journal of pain research · 2022Article
- A lasting symbiosis: how the Hawaiian bobtail squid finds and keeps its bioluminescent bacterial partner.Nature reviews. Microbiology · 2021Review
- Injury alters motivational trade-offs in calves during the healing period.Scientific reports · 2021Article
- Behavioral and neurophysiological evidence suggests affective pain experience in octopus.iScience · 2021Article
- Evolution of mechanisms and behaviour important for pain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Injury occurring in the neonatal period in mammals is known to induce plasticity in pain pathways that may lead to pain dysfunction in later life. Whether these effects are unique to the mammalian nervous system is not well understood. Here, we investigate whether similar effects of early-life injury are found in a large-brained comparative model, the cephalopod
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.