ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
Evolution of nociception and pain: evidence from fish models.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 177 citations in OpenAlex.
- Development of the capacity to suffer in embryos and chicks: a systematic review of relevant studies.Frontiers in veterinary science · 2025Pooled it
- Good Anesthesia Practice for Fish and Other Aquatics.Biology · 2022Guideline
- Effect of Lidocaine as an Adjuvant to Clove Essential Oil on Anaesthetic Induction and Recovery in Nile Tilapia.Journal of fish diseases · 2026Article
- Cannabis-Based Nanolipid Formulations for Pain Management.Pharmaceutics · 2026Review
- Effects of analgesia on the response to a noxious stimulus in Norway lobsters (Nephrops norvegicus).Scientific reports · 2026Article
- The Pro- But Not Antinociceptive Effects of Cannabidiol Depend on Trpa1b in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Empathy for pain in humans and animals differs based on species, psychosocial and cultural factors.Scientific reports · 2026Article
- Euthanasia Methods in Invertebrates: A Critical Narrative Review of Methodological and Welfare Standards.Animals : an open access journal from MDPI · 2026Review
- Tricaine methanesulfonate and eugenol during semen collection do not affect fertilization and hatching rates onAnimal reproduction · 2026Article
- The pro-, but not anti-nociceptive effects of Cannabidiol depend on Trpa1b in larval Zebrafish.bioRxiv : the preprint server for biology · 2025Article
- From nociception in aneural animals to human suffering: toward a comparative biology of pain.The Journal of experimental biology · 2025Review
- Language Should Reflect Biological Knowledge.Animals : an open access journal from MDPI · 2025Article
- Editorial: Fish Welfare in Aquaculture and Research-Where Are We Going?Animals : an open access journal from MDPI · 2025Article
- Honeybee Sentience: Scientific Evidence and Implications for EU Animal Welfare Policy.Veterinary sciences · 2025Article
- Advancing Zebrafish (Veterinary sciences · 2025Review
- Quantifying the welfare impact of air asphyxia in rainbow trout slaughter for policy and practice.Scientific reports · 2025Article
- Analysis of the cardiotoxic and myorelaxant effects of camphor on fish of the Nile tilapia species (Oreochromis niloticus) (Linnaeus 1758).Scientific reports · 2025Article
- A distributed brain response predicting the facial expression of acute nociceptive pain.eLife · 2024Article
- Article
- Cutaneous Wound Healing and the Effects of Cannabidiol.International journal of molecular sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
In order to survive, animals must avoid injury and be able to detect potentially damaging stimuli via nociceptive mechanisms. If the injury is accompanied by a negative affective component, future behaviour should be altered and one can conclude the animal experienced the discomfort associated with pain. Fishes are the most successful vertebrate group when considering the number of species that have filled a variety of aquatic niches. The empirical evidence for nociception in fishes from the underlying molecular biology, neurobiology and anatomy of nociceptors through to whole animal behavioural responses is reviewed to demonstrate the evolutionary conservation of nociception and pain from invertebrates to vertebrates. Studies in fish have shown that the biology of the nociceptive system is strikingly similar to that found in mammals. Further, potentially painful events result in behavioural and physiological changes such as reduced activity, guarding behaviour, suspension of normal behaviour, increased ventilation rate and abnormal behaviours which are all prevented by the use of pain-relieving drugs. Fish also perform competing tasks less well when treated with a putative painful stimulus. Therefore, there is ample evidence to demonstrate that it is highly likely that fish experience pain and that pain-related behavioural changes are conserved across vertebrates. This article is part of the Theo Murphy meeting issue 'Evolution of mechanisms and behaviour important for pain'.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.