ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
Evolution of mechanisms and behaviour important for pain.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Trial
- The Impact of Emotional Arousal on Physical Pain and Numbness in Individuals Who Engage in Non-Suicidal Self-Injury.Suicide & life-threatening behavior · 2026Article
- Integrative GC-MS, FT-IR, and Molecular Docking Analysis ofFood science & nutrition · 2026Article
- Chronic Pain Acceptance Moderates the Association Between Pain Intensity and Alcohol Use Severity Among Veterans With Chronic Musculoskeletal Pain.Alcohol, clinical & experimental research · 2026Article
- Article
- Wild strains reveal natural variation in C. elegans avoidance behaviors.G3 (Bethesda, Md.) · 2025Article
- Antinociceptive effect of Arvelexin in male mouse models.Scientific reports · 2025Article
- From nociception in aneural animals to human suffering: toward a comparative biology of pain.The Journal of experimental biology · 2025Review
- Approved Ambiguities: An Analysis of Applications for the Ethical Review of Animal Research in Sweden-Focusing on Harm, Benefit, and the 3Rs.Animals : an open access journal from MDPI · 2025Article
- Ratio of excitatory and inhibitory synaptic processes in periaqueductal gray matter of the brain activated by the raphe magnus nucleus in a model of Parkinson's disease with hydrocortisone protection.The Korean journal of pain · 2025Article
- Enhanced behavioural and neural sensitivity to punishments in chronic pain and fatigue.Brain : a journal of neurology · 2025Article
- Do some people with a prolonged disorder of consciousness experience pain? A clinically focused narrative review and synthesis.Clinical rehabilitation · 2025Review
- Reconfiguring Pain Interpretation Within a Social Model of Health Using a Simplified Version of Wilber's All Quadrant All Levels Framework: An Integral Vision.Behavioral sciences (Basel, Switzerland) · 2025Article
- The Role of TNF-α in Neuropathic Pain: An Immunotherapeutic Perspective.Life (Basel, Switzerland) · 2025Review
- Injury alters sensory, motor, and integrative elements underlying operant conditioning in the medicinal leech.PloS one · 2025Article
- Clinical Applications and Future Translation of Somatosensory Neuroprostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Article
- Antinociceptive Analysis of Natural Monoterpenes Eugenol, Menthol, Carvacrol and Thymol in a Zebrafish Larval Model.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Article
- Repetitive nociceptive stimulation elicits complex behavioral changes in Hirudo: evidence of arousal and motivational adaptations.The Journal of experimental biology · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our understanding of the biology of pain is limited by our ignorance about its evolution. We know little about how states in other species showing various degrees of apparent similarity to human pain states are related to human pain, or how the mechanisms essential for pain-related states evolved. Nevertheless, insights into the evolution of mechanisms and behaviour important for pain are beginning to emerge from wide-ranging investigations of cellular mechanisms and behavioural responses linked to nociceptor activation, tissue injury, inflammation and the environmental context of these responses in diverse species. In February 2019, an unprecedented meeting on the evolution of pain hosted by the Royal Society brought together scientists from disparate fields who investigate nociception and pain-related behaviour in crustaceans, insects, leeches, gastropod and cephalopod molluscs, fish and mammals (primarily rodents and humans). Here, we identify evolutionary themes that connect these research efforts, including adaptive and maladaptive features of pain-related behavioural and neuronal alterations-some of which are quite general, and some that may apply primarily to humans. We also highlight major questions, including how pain should be defined, that need to be answered as we seek to understand the evolution of pain. This article is part of the Theo Murphy meeting issue 'Evolution of mechanisms and behaviour important for pain'.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.