ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
Listening to your gut: immune challenge to the gut sensitizes body wall nociception in the caterpillar
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Neuroimmune Pain and Its Manipulation by Pathogens.Evolutionary applications · 2025Article
- The caterpillar Manduca sexta brain shows changes in gene expression and protein abundance correlating with parasitic manipulation of behaviour.Scientific reports · 2024Article
- Muscle in the caterpillar Manduca sexta responds to an immune challenge, but at a cost, suggesting a physiological trade-off.The Journal of experimental biology · 2023Article
- Host species differences in the thermal mismatch of host-parasitoid interactions.The Journal of experimental biology · 2023Article
- Phylogenetic Analysis Provides Insight Into the Molecular Evolution of Nociception and Pain-Related Proteins.Evolutionary bioinformatics online · 2023Article
- Animals have a Plan B: how insects deal with the dual challenge of predators and pathogens.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Review
- Evolution of mechanisms and behaviour important for pain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Immune-nociceptor connections are found in animals across phyla. Local inflammation and/or damage results in increased nociceptive sensitivity of the affected area. However, in mammals, immune responses far from peripheral nociceptors, such as immune responses in the gut, produce a general increase in peripheral nociceptive sensitivity. This phenomenon has not, to our knowledge, been found in other animal groups. We found that consuming heat-killed pathogens reduced the tactile force needed to induce a defensive strike in the caterpillar
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