ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 57 citations in OpenAlex.
- TRP channel activation and cholinergic signaling in insect thermoregulation: evidence from the American cockroach.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Multimodal targets of (-)-α-thujone mediating avoidance behavior of a stored-products pest, Tribolium castaneum, in response to irritant stimuli.Pest management science · 2026Article
- Integrative screening of plant volatiles through transient receptor potential channel docking, olfactometry, and field validation in Bemisia tabaci.Pest management science · 2026Article
- Evolution in metazoans of the TRPM channel family involves multiple gains and losses of genes and domains.Molecular biology and evolution · 2026Article
- Neural substrates of cold nociception ineLife · 2025Article
- HL-TRP channel is required for various repellents for the parthenogenetic Haemaphysalis longicornis.Parasites & vectors · 2025Article
- Evolution of Sensory Receptors.Annual review of cell and developmental biology · 2024Review
- Draft Genome of Akame (Lates Japonicus) Reveals Possible Genetic Mechanisms for Long-Term Persistence and Adaptive Evolution with Low Genetic Diversity.Genome biology and evolution · 2024Article
- Evidence that the cold- and menthol-sensing functions of the human TRPM8 channel evolved separately.Science advances · 2024Article
- Cold-Temperature Coding with Bursting and Spiking Based on TRP Channel Dynamics inInternational journal of molecular sciences · 2023Article
- Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization ineLife · 2023Article
- Nociception in fruit fly larvae.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Noxious chemical discrimination byCurrent research in insect science · 2023Article
- Phylogenetic Analysis Provides Insight Into the Molecular Evolution of Nociception and Pain-Related Proteins.Evolutionary bioinformatics online · 2023Article
- TRPA1-mediated repellency behavior in the red flour beetle Tribolium castaneum.Scientific reports · 2022Article
- Genome-Wide Identification of the Long Noncoding RNAs ofInsects · 2022Article
- Modality specific roles for metabotropic GABAergic signaling and calcium induced calcium release mechanisms in regulating cold nociception.Frontiers in molecular neuroscience · 2022Article
- Activation ofInternational journal of molecular sciences · 2021Article
- Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior.Development (Cambridge, England) · 2021Article
- Regulation of the antennal transcriptome of the dengue vector, Aedes aegypti, during the first gonotrophic cycle.BMC genomics · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Transient receptor potential (TRP) cation channels are highly conserved, polymodal sensors which respond to a wide variety of stimuli. Perhaps most notably, TRP channels serve critical functions in nociception and pain. A growing body of evidence suggests that transient receptor potential melastatin (TRPM) and transient receptor potential ankyrin (TRPA) thermal and electrophile sensitivities predate the protostome-deuterostome split (greater than 550 Ma). However, TRPM and TRPA channels are also thought to detect modified terpenes (e.g. menthol). Although terpenoids like menthol are thought to be aversive and/or harmful to insects, mechanistic sensitivity studies have been largely restricted to chordates. Furthermore, it is unknown if TRP-menthol sensing is as ancient as thermal and/or electrophile sensitivity. Combining genetic, optical, electrophysiological, behavioural and phylogenetic approaches, we tested the hypothesis that insect TRP channels play a conserved role in menthol sensing. We found that topical application of menthol to
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.