Evidence map›Paper›PMID 31544233›Full record

ArticleCancer2019

Chinese nonmedicinal herbal diet and risk of nasopharyngeal carcinoma: A population-based case-control study.

Chuyang Lin, Su-Mei Cao, Ellen T Chang, Zhiwei Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Yu Zhang and 13 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Anticancer Mechanism ofPharmaceuticals (Basel, Switzerland) · 2024
    Review
  7. Article
  8. Article
  9. Nasopharyngeal carcinoma. A "different" head and neck tumour. Part A: from histology to staging.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2023
    Review
  10. Article
  11. A novel causal model for nasopharyngeal carcinoma.Cancer causes & control : CCC · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 4 countries.

Chuyang LinDepartment of Cancer Prevention Center, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Su-Mei CaoDepartment of Cancer Prevention Center, Sun Yat-Sen University Cancer Center, Guangzhou, China.ORCID 0000-0003-1749-517X
Ellen T ChangCenter for Health Sciences, Exponent, Inc, Menlo Park, California.
Zhiwei LiuDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Yonglin CaiDepartment of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, China.
Zhe ZhangDepartment of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Guomin ChenState Key Laboratory for Infectious Diseases Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Qi-Hong HuangSihui Cancer Institute, Sihui, China.
Shang-Hang XieDepartment of Cancer Prevention Center, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Yu ZhangState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, and Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Jingping YunState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, and Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Wei-Hua JiaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, and Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Yuming ZhengDepartment of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, China.
Jian LiaoCangwu Institute for Nasopharyngeal Carcinoma Control and Prevention, Wuzhou, China.
Yufeng ChenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Longde LinKey Laboratory of High-Incidence-Tumor Prevention and Treatment (Guangxi Medical University), Ministry of Education, Nanning, China.
Qing LiuDepartment of Cancer Prevention Center, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Ingemar ErnbergDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
Guangwu HuangDepartment of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yi ZengState Key Laboratory for Infectious Diseases Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Yi-Xin ZengState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, and Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Hans-Olov AdamiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Weimin YeDepartment of Cancer Prevention Center, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Sun Yat-sen University · CNKarolinska Institutet · SEFirst Affiliated Hospital of GuangXi Medical University · CNWuzhou University · CNCancer Prevention Institute of California · USTumor Hospital of Guangxi Medical University · CNUniversity of Oslo · NO

Funding

Gene-environment EBV Interactions in the Etiology of Nasopharyngeal Carcinoma (NPR01CA115873 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI ADAMI, HANS-OLOV · 2008 to 2013
$2.4M
Guangxi Natural Science Foundation 2013GXNSFGA 019002Karolinska Institute Dnr 2368/10-221Karolinska Institutet Distinguished Professor Award Dnr: 2368/10-221National Basic Research Program of China 2011CB504300National Key Research and Development Program of China 2017YFC0907100National Natural Science Foundation of China 81872700Natural Science Foundation of China 81872700Natural Science Foundation of Guangxi Province 2013GXNSFGA 019002NCI NIH HHS R01 CA115873New Century Excellent Talents in University NCET-12-0654Program for New Century Excellent Talents in University NCET-12-0654Swedish Research Council 2015-02625Swedish Research Council 2015-02625, 2015-06268, 2017-05814Swedish Research Council 2015-06268Swedish Research Council 2017-05814The National Key Research and Development Program of China 2017YFC0907100
6 · The paper itself

Abstract

backgroundAn association between a nonmedicinal herbal diet and nasopharyngeal carcinoma (NPC) has often been hypothesized but never thoroughly investigated.

methodsThis study enrolled a total of 2469 patients with incident NPC and 2559 population controls from parts of Guangdong and Guangxi Provinces in southern China between 2010 and 2014. Questionnaire information was collected on the intake of traditional herbal tea and herbal soup as well as the specific herbal plants used in soups and other potentially confounding lifestyle factors. Multivariate logistic regression models were used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for the NPC risk in association with herbal tea and soup intake.

resultsEver consumption of herbal tea was not associated with NPC risk (OR, 1.03; 95% CI, 0.91-1.17). An inverse association was observed for NPC among ever drinkers of herbal soup (OR, 0.78; 95% CI, 0.67-0.90) but without any monotonic trend with an increasing frequency or duration of herbal soup consumption. Inverse associations with NPC risk were detected with 9 herbal plants used in herbal soup, including Ziziphus jujuba, Fructus lycii, Codonopsis pilosula, Astragalus membranaceus, Semen coicis, Smilax glabra, Phaseolus calcaratus, Morinda officinalis, and Atractylodes macrocephala (OR range, 0.31-0.79).

conclusionsConsuming herbal soups including specific plants, but not herbal tea, was inversely associated with NPC. If replicated, these results might provide potential for NPC prevention in endemic areas.

Indexed as

DietAdultAgedCase-Control StudiesDisease SusceptibilityFemaleHumansMaleMiddle AgedNasopharyngeal CarcinomaOdds RatioPopulation SurveillanceRisk FactorsYoung Adultcase-control studiesherbal dietherbsnasopharyngeal carcinoma

Identifiers

PMID31544233
PMCPMC6891117
OpenAlexW2975205853

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.