Evidence map›Paper›PMID 31544220›Full record

ArticleClinical and experimental nephrology2020

Association of depressive symptoms with 25(OH) vitamin D in hemodialysis patients and effect of gender.

Yasemin Coskun Yavuz, Zeynep Biyik, Durmus Ozkul, Sedat Abusoglu, Duygu Eryavuz, Mikail Dag, Muslu Kazim Korez, Ibrahim Guney, Lutfullah Altintepe

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Clinical and experimental nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yasemin Coskun YavuzInternal Medicine Department, Selcuk University Faculty of Medicine, Konya, Turkey. yasemincoskun@yahoo.com.ORCID http://orcid.org/0000-0003-1733-9003
Zeynep BiyikInternal Medicine Department, Selcuk University Faculty of Medicine, Konya, Turkey.
Durmus OzkulInternal Medicine Department, Konya Training and Research Hospital, Konya, Turkey.
Sedat AbusogluBiochemistry Department, Selcuk University Faculty of Medicine, Konya, Turkey.
Duygu EryavuzBiochemistry Department, Selcuk University Faculty of Medicine, Konya, Turkey.
Mikail DagBiochemistry Department, Selcuk University Faculty of Medicine, Konya, Turkey.
Muslu Kazim KorezStatistics Department, Selcuk University Faculty of Science, Konya, Turkey.
Ibrahim GuneyNephrology Department, Konya Training and Research Hospital, Konya, Turkey.
Lutfullah AltintepeInternal Medicine Department, Selcuk University Faculty of Medicine, Konya, Turkey.
Selçuk University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression is common in chronic kidney disease (CKD) patients and associated with significant increase in morbidity and mortality. In recent years, a relationship between vitamin D deficiency and depression has been shown. The aim of this study is to investigate the relationship between 25-hydroxy (OH) vitamin D and depression in hemodialysis patients.

methodsA total of 140 patients were included in the study. Hamilton depression scale (HAM-D) was completed by all patients. 25(OH) vitamin D levels were compared between patients with and without depressive symptoms.

resultsPatients who had depressive symptoms had significantly lower 25(OH) vitamin D levels (13.70 [24.3-8.25] vs. 18.20 [29.2-11.7] ng/mL, p = 0.016). HAM-D score showed significant association with gender (p = 0.011) and 25(OH) vitamin D level (p = 0.011). Univariate logistic regression analysis showed that males had lower risk of depression by a ratio of 61.1% (OR 0.389, p = 0.012) and vitamin D-deficient patients had 2.88 times greater risk of depression compared to non-deficient patients (OR 2.885, p = 0.013). Multivariate logistic regression analysis showed that males had 53.7% less risk of depression (OR 0.463, p = 0.046) and vitamin D-deficient patients had 2.39 times greater risk of depression (OR 2.397, p = 0.047). When evaluated by gender, univariate logistic regression analysis showed that 25(OH) vitamin D and other variables were not associated with depression in females (p > 0.05), while only vitamin D level had a significant effect on depression in males (OR 8.207, p = 0.008).

conclusionsWe found a significant association between vitamin D level and depressive symptoms in hemodialysis patients. When analyzed according to gender, this association was found to stand independent of other variables only in males.

Indexed as

AffectRenal DialysisAdolescentAdultAgedAged, 80 and overBiomarkersCross-Sectional StudiesDepressionFemaleHumansMaleMiddle AgedPrevalenceRenal Insufficiency, ChronicRisk Assessment25-hydroxyvitamin DBiomarkersVitamin DDepressionGenderHemodialysisVitamin D

Identifiers

PMID31544220
OpenAlexW2976857290

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.