Evidence map›Paper›PMID 31544111›Full record

ReviewERJ open research2019

Oxygen therapy in COPD and interstitial lung disease: navigating the knowns and unknowns.

Yet H Khor, Elisabetta A Renzoni, Dina Visca, Christine F McDonald, Nicole S L Goh

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in ERJ open research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07512687 (Impact of Ambulatory Oxygen Delivery on Real-world Activity and Quality-of-life in Patients With Interstitial Lung Disease), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07512687 narecruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Ambulatory Oxygen Delivery on Real-world Activity and Quality-of-life in Patients With Interstitial Lung Disease (ILD) and Chronic Obstructive Pulmonary Disease (COPD)

TypeinterventionalSponsorState University of New York at BuffaloRan2026 to 2027Enrolled24ConditionsInterstitial Lung Disease, Chronic Obstructive Pulmonary Disease, HypoxemiaArmsPortable Oxygen Concentrator, Portable compressed oxygen D-tanks, No ambulatory oxygen therapy
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Advanced interstitial lung disease: Evidence-based management and clinical approach.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
    Article
  5. Five-Year Survival and Associated Factors in COPD Patients in Colombia: A Retrospective Cohort Study.International journal of chronic obstructive pulmonary disease · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. 2022 Brazilian Thoracic Association recommendations for long-term home oxygen therapy.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Long-term oxygen therapy - Supplement, maintenance, or palliative drug?Lung India : official organ of Indian Chest Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Yet H KhorDept of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Australia.ORCID https://orcid.org/0000-0002-5434-9342
Elisabetta A RenzoniInterstitial Lung Disease Unit, Royal Brompton Hospital, Imperial College London, London, UK.
Dina ViscaDivision of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri, IRCCS, Tradate, Italy.ORCID https://orcid.org/0000-0003-2298-1623
Christine F McDonaldDept of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Australia.
Nicole S L GohDept of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Australia.
The University of Melbourne · AUInstitute for Breathing and Sleep · AURoyal Brompton Hospital · GBUniversity of Insubria · IT

Funding

Department of Health PB-PG-0712-28073Versus Arthritis 20719
6 · The paper itself

Abstract

Domiciliary oxygen therapy is often prescribed for patients with hypoxaemia due to advanced lung disease, most commonly chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). Long-term oxygen therapy (LTOT) trials conducted in patients with COPD in the 1980s remain the basis for clinical decisions and guideline recommendations regarding LTOT for patients with non-COPD conditions as there is a lack of high-quality evidence concerning its use in the non-COPD population. There is also a lack of evidence for the use of ambulatory and nocturnal oxygen therapy in patients with isolated exertional and nocturnal hypoxaemia. These deficiencies pose significant challenges in patient care, with consequent discrepancies in guideline recommendations and clinical approaches. In recent years, new studies have been and are currently being conducted to fill the gaps in our understanding and use of domiciliary oxygen therapy for other indications, including ILD. This article provides a comparison of the epidemiology and significance of hypoxaemia in patients with COPD and ILD, with an up-to-date review of current evidence regarding the role of different types of domiciliary oxygen therapy in these conditions.

Identifiers

PMID31544111
PMCPMC6745413
OpenAlexW2973614780

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.