Evidence map›Paper›PMID 31543961›Full record

ArticleMaterials chemistry frontiers2019

A Versatile Catalyst-Free Perfluoroaryl Azide-Aldehyde-Amine Conjugation Reaction.

Sheng Xie, Juan Zhou, Xuan Chen, Na Kong, Yanmiao Fan, Yang Zhang, Gerry Hammer, David G Castner, Olof Ramström, Mingdi Yan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials chemistry frontiers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Quantification of binding affinity of glyconanomaterials with lectins.Chemical communications (Cambridge, England) · 2020
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Sheng XieDepartment of Chemistry, KTH-Royal Institute of Technology, Stockholm, Sweden.
Juan ZhouDepartment of Chemistry, KTH-Royal Institute of Technology, Stockholm, Sweden.
Xuan ChenDepartment of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854, USA. E-mail: mingdi_yan@uml.edu, olof_ramstrom@uml.edu.
Na KongDepartment of Chemistry, KTH-Royal Institute of Technology, Stockholm, Sweden.
Yanmiao FanDepartment of Chemistry, KTH-Royal Institute of Technology, Stockholm, Sweden.
Yang ZhangDepartment of Chemistry, KTH-Royal Institute of Technology, Stockholm, Sweden.
Gerry HammerDepartments of Bioengineering and Chemical Engineering, National ESCA and Surface Analysis Center for Biomedical Problems, University of Washington, Seattle, Washington, USA.
David G CastnerDepartments of Bioengineering and Chemical Engineering, National ESCA and Surface Analysis Center for Biomedical Problems, University of Washington, Seattle, Washington, USA.
Olof RamströmDepartment of Chemistry, KTH-Royal Institute of Technology, Stockholm, Sweden.
Mingdi YanDepartment of Chemistry, KTH-Royal Institute of Technology, Stockholm, Sweden.
KTH Royal Institute of Technology · SEUniversity of Massachusetts Lowell · USUniversity of Washington · USHunan University · CNJiangnan University · CN

Funding

Surface Analysis Facility for Biomedical ProblemsP41EB002027 · NIBIB · UNIVERSITY OF WASHINGTON · PI CASTNER, DAVID G · 2003 to 2019
$17.6M
Photogenerated Carbohydrate MicroarraysR01GM080295 · NIGMS · UNIVERSITY OF MASSACHUSETTS LOWELL · PI YAN, MINGDI · 2008 to 2012
$2.0M
Maltoheptaose based nanotherapeutics for multidrug resistant bacterial infectionR21AI109896 · NIAID · UNIVERSITY OF MASSACHUSETTS LOWELL · PI YAN, MINGDI · 2014 to 2015
$444k
Glycosylated Atomically-Precise Gold Clusters: Design, Synthesis and Antimicrobial ActivityR21AI140418 · NIAID · UNIVERSITY OF MASSACHUSETTS LOWELL · PI YAN, MINGDI · 2018 to 2019
$419k
NIAID NIH HHS R21 AI109896NIAID NIH HHS R21 AI140418NIBIB NIH HHS P41 EB002027NIGMS NIH HHS R01 GM080295
6 · The paper itself

Abstract

A tri-component reaction, involving an electrophilically-activated perfluoroaryl azide, an enolizable aldehyde and an amine, reacts readily at room temperature without any catalysts in solvents including aqueous conditions to yield a stable amidine conjugate. The versatility of this reaction is demonstrated in the conjugation of an amino acid without prior protection of the carboxyl group, and in the synthesize antibiotic-nanoparticle conjugates.

Identifiers

PMID31543961
PMCPMC6754110
OpenAlexW2902860976

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.