ArticleFrontiers in physiology2019
Sodium Butyrate Modulates Mucosal Inflammation Injury Mediated by GPR41/43 in the Cecum of Goats Fed a High Concentration Diet.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Butyrate ameliorates maternal high-fat-diet-induced placental inflammation and offspring metabolic dysfunction via modulating gut microbiota in mice.European journal of nutrition · 2026Article
- Methylation and expression dynamics in broiler liver followingJournal of veterinary research · 2026Article
- Sex-Specific Diet-Microbiota Interactions in Ageing: Implications for Healthy Longevity.Nutrients · 2025Review
- Gastrointestinal development and tight junctions of preweaned calves supplemented with sodium butyrate in the starter mixture and whole milk.Tropical animal health and production · 2025Article
- Butyrate Supplementation Improves Intestinal Health and Growth Performance in Livestock: A Review.Biomolecules · 2025Review
- Gut microbiota dysbiosis and systemic inflammation in elderly Chinese hypertensive patients: a case-control study.Frontiers in immunology · 2025Article
- Protein modification by short-chain fatty acid metabolites in sepsis: a comprehensive review.Frontiers in immunology · 2023Review
- Roughage quality determines the production performance of post-weaned Hu sheep via altering ruminal fermentation, morphology, microbiota, and the global methylome landscape of the rumen wall.Frontiers in microbiomes · 2023Article
- Feedlot diets containing different starch levels and additives change the cecal proteome involved in cattle's energy metabolism and inflammatory response.Scientific reports · 2022Article
- Centenarian-SourcedNutrients · 2022Article
- Age-dependent changes of hindgut microbiota succession and metabolic function of Mongolian cattle in the semi-arid rangelands.Frontiers in microbiology · 2022Article
- The Future of Gastrointestinal Physiology: 2020 and Beyond.Frontiers in physiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging data indicate that excessive short chain fatty acids can mediate the downstream mitogen-activated protein kinase pathways by activating G-protein coupled receptor 41/43 (GPR41/43) to initiate the inflammatory response. The current study was conducted to investigate if a high concentrate (HC) supplemented with sodium butyrate can alleviate the inflammation and if an epigenetic mechanism is involved in regulating the expression of the key GPR41/43 genes in the cecum. Twelve lactating goats were randomly divided into two groups: the control group fed the HC diet and the treatment group fed the HC diet supplemented with sodium butyrate (HCB). Our results suggested that the supplementation of sodium butyrate significantly increased the pH value in the rumen and cecum, downregulated the expression of GPR41/43 and related inflammatory cytokines, upregulated the expression of tight junction proteins, and reduced the protein expression levels of GPR 41/43, ERK1/2, and p38. Moreover, the ratios of DNA methylation and chromatin compaction in the promoter region of the GPR41/43 genes were altered due to the addition of sodium butyrate. In brief, dietary addition of sodium butyrate can reduce the inflammatory injury to the cecal mucosa in lactating goats and can affect the expression of GPR41/43 via epigenetic modification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.