ArticleFrontiers in aging neuroscience2019
Effects of Acupuncture Therapy on MCI Patients Using Functional Near-Infrared Spectroscopy.
Article in Frontiers in aging neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 6 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 6 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Identification of functional near-infrared spectroscopy for older adults with mild cognitive impairment: a systematic review.Frontiers in aging neuroscience · 2025Pooled it
- Alterations in brain functional connectivity in patients with mild cognitive impairment: A systematic review and meta-analysis of functional near-infrared spectroscopy studies.Brain and behavior · 2024Pooled it
- Efficacy and safety of acupuncture for cognitive impairment in Alzheimer's disease: a systematic review and meta-analysis.Frontiers in dementia · 2024Pooled it
- Association of nonpharmacological interventions for cognitive function in older adults with mild cognitive impairment: a systematic review and network meta-analysis.Aging clinical and experimental research · 2023Pooled it
- Acupuncture on mild cognitive impairment: A systematic review of neuroimaging studies.Frontiers in aging neuroscience · 2023Pooled it
- Bibliometric analysis: Research trends of acupuncture treatment to cognitive impairment in recent 15 years.Frontiers in psychology · 2022Pooled it
- LR3-LI4 needling side and configuration are associated with phase-specific cortical activation and network organization: a functional near-infrared spectroscopy study in healthy adults.Frontiers in neurology · 2026Trial
- The effects of combining anodal transcranial direct current stimulation with robot-assisted gait training on lower limb motor function and the motor cortex regulation of stroke patients.Journal of neuroengineering and rehabilitation · 2025Trial
- The increased inter-brain neural synchronization in prefrontal cortex between simulated patient and acupuncturist during acupuncture stimulation: Evidence from functional near-infrared spectroscopy hyperscanning.Human brain mapping · 2023Trial
- Prefrontal hemodynamic alterations during resting state and stroop interference in cognitively healthy older adults with high plasma pTau-217 levels.Neuroimage. Reports · 2026Article
- The Therapeutic Efficacy of Gold Needle "Regulating Spirit" Acupuncture for Amnestic Mild Cognitive Impairment: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2026Article
- Acupuncture for Post-Stroke Cognitive Impairment: Mechanisms and Clinical Evidence (2020-2025).Neuropsychiatric disease and treatment · 2026Review
- Enhanced fNIRS-Based MCI Detection via Resting-State and Task-State Integration With Spatial-Temporal Feature Reduction.IEEE journal of translational engineering in health and medicine · 2026Article
- Article
- Neural Mechanism of Cognitive Reserve in Acupuncture Stimulation: Protocol for a Randomized, Placebo-Controlled Functional Near-Infrared Spectroscopy Trial.JMIR research protocols · 2025Article
- Exploring Effects of Mental Stress with Data Augmentation and Classification Using fNIRS.Sensors (Basel, Switzerland) · 2025Article
- Effectiveness and safety of thread embedding acupuncture for facial nerve palsy sequelae: a protocol for a multicenter, assessor-blinded, randomized, controlled clinical trial.Frontiers in neurology · 2025Article
- Analysis of the application of functional near-infrared spectroscopy in acupuncture research: a review.Frontiers in neurology · 2025Review
- Observational
- Acupuncture modulates the microbiota-gut-brain axis: a novel therapeutic strategy for amnestic mild cognitive impairment.Frontiers in neuroscience · 2025Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acupuncture therapy (AT) is a non-pharmacological method of treatment that has been applied to various neurological diseases. However, studies on its longitudinal effect on the neural mechanisms of patients with mild cognitive impairment (MCI) for treatment purposes are still lacking in the literature. In this clinical study, we assess the longitudinal effects of ATs on MCI patients using two methods: (i) Montreal Cognitive Assessment test (MoCA-K, Korean version), and (ii) the hemodynamic response (HR) analyses using functional near-infrared spectroscopy (fNIRS). fNIRS signals of a working memory (WM) task were acquired from the prefrontal cortex. Twelve elderly MCI patients and 12 healthy people were recruited as target and healthy control (HC) groups, respectively. Each group went through an fNIRS scanning procedure three times: The initial data were obtained without any ATs, and subsequently a total of 24 AT sessions were conducted for MCI patients (i.e., MCI-0: the data prior to ATs, MCI-1: after 12 sessions of ATs for 6 weeks, MCI-2: another 12 sessions of ATs for 6 weeks). The mean HR responses of all MCI-0-2 cases were lower than those of HCs. To compare the effects of AT on MCI patients, MoCA-K results, temporal HR data, and spatial activation patterns (i.e.,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.