ReviewWorld journal of gastroenterology2019
Neoadjuvant radiotherapy for rectal cancer management.
Review in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 140 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predictors of Disease Free Survival After Curative Cancer Rectum Surgery
A Phase III, Multi-institutional Randomised Trial Comparing Neoadjuvant Chemoradiotherapy (NARCT) and Total Neoadjuvant Therapy (TNT) in Patients With T3 (a/b/c) Rectal Cancer
ctDNA Monitoring to Predict the Efficacy of Total Neoadjuvant Therapy for Rectal Cancer
Who cites it
140 citing papers in PubMed, 4 syntheses or guidelines pooled it, 268 citations in OpenAlex.
- Outcomes of the management of synchronous rectal and prostate cancer: a systematic review.International journal of colorectal disease · 2025Pooled it
- Machine learning in predicting pathological complete response to neoadjuvant chemoradiotherapy in rectal cancer using MRI: a systematic review and meta-analysis.The British journal of radiology · 2024Pooled it
- Mixed epithelial endocrine neoplasms of the colon and rectum - An evolution over time: A systematic review.World journal of gastroenterology · 2020Pooled it
- Efficacy and safety of wait and see strategy versus radical surgery and local excision for rectal cancer with cCR response after neoadjuvant chemoradiotherapy: a meta-analysis.World journal of surgical oncology · 2020Pooled it
- Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes from an open-label, dose-escalation, single-center, phase I/II clinical trial.Frontiers of medicine · 2023Trial
- Evaluation of Nursing Effects of Pelvic Floor Muscle Rehabilitation Exercise on Gastrointestinal Tract Rectal Cancer Patients Receiving Anus-preserving Operation by Intelligent Algorithm-based Magnetic Resonance Imaging.Contrast media & molecular imaging · 2022Trial
- [Combination of radiotherapy and medicinal anticancer therapy with curative intent].Radiologie (Heidelberg, Germany) · 2026Article
- The CHRONO trial: Protocol for a randomized controlled trial of early time-restricted eating in patients with breast or rectal cancer.Nutrition research (New York, N.Y.) · 2026Article
- Decision making and outcomes in colorectal cancer and frailty: the DeCaF study.Annals of the Royal College of Surgeons of England · 2026Article
- Prediction of tumor regression grading in rectal cancer neoadjuvant chemoradiotherapy: a habitat radiomics analysis of imaging biomarker.BMC medical imaging · 2026Article
- Margin-driven outcomes prevail over resection planes: multivisceral surgery matches total mesorectal excision in locally advanced rectal cancer.Annals of coloproctology · 2026Article
- Feasibility of Clinically Prioritized Colorectal Cancer Quality Indicators With a New South Wales Population-Based Linked Dataset.Asia-Pacific journal of clinical oncology · 2026Article
- Article
- Gastrointestinal Toxicity and Clinical Predictors of Total Neoadjuvant Therapy in Rectal Cancer: A Real-World Retrospective Study.Life (Basel, Switzerland) · 2026Article
- Effectiveness and outcome of gracilis muscle flap reconstruction following perineal surgery: a retrospective single-center cohort study.Annals of medicine and surgery (2012) · 2026Article
- Research Advances in Nanodrugs Targeting Lipid Metabolism Reprogramming for Colorectal Cancer Therapy.International journal of nanomedicine · 2026Review
- Integrating clinical and genomic features to predict response to neoadjuvant therapy in microsatellite-stable rectal cancer.Therapeutic advances in medical oncology · 2026Article
- Quality of Life after Laparoscopic Sphincter-Preserving Total Mesorectal Excision for Low Rectal Cancer: A Single-Center Prospective Cohort Study in Vietnam.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- A single dose of neoadjuvant radiation for Merkel cell carcinoma: Complete pathologic response with minimal morbidity in a rapidly growing lesion of the eye.JAAD case reports · 2025Article
- Prophylactic negative pressure wound therapy with Prevena™ to prevent perineal surgical site infection.Surgery today · 2025Article
80 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thirty per cent of all colorectal tumours develop in the rectum. The location of the rectum within the bony pelvis and its proximity to vital structures presents significant therapeutic challenges when considering neoadjuvant options and surgical interventions. Most patients with early rectal cancer can be adequately managed by surgery alone. However, a significant proportion of patients with rectal cancer present with locally advanced disease and will potentially benefit from down staging prior to surgery. Neoadjuvant therapy involves a variety of options including radiotherapy, chemotherapy used alone or in combination. Neoadjuvant radiotherapy in rectal cancer has been shown to be effective in reducing tumour burden in advance of curative surgery. The gold standard surgical rectal cancer management aims to achieve surgical removal of the tumour and all draining lymph nodes, within an intact mesorectal package, in order to minimise local recurrence. It is critically important that all rectal cancer cases are discussed at a multidisciplinary meeting represented by all relevant specialties. Pre-operative staging including CT thorax, abdomen, pelvis to assess for distal disease and magnetic resonance imaging to assess local involvement is essential. Staging radiology and MDT discussion are integral in identifying patients who require neoadjuvant radiotherapy. While Neoadjuvant radiotherapy is potentially beneficial it may also result in morbidity and thus should be reserved for those patients who are at a high risk of local failure, which includes patients with nodal involvement, extramural venous invasion and threatened circumferential margin. The aim of this review is to discuss the role of neoadjuvant radiotherapy in the management of rectal cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.